1. Lectures posted online after lecture. Textbook sections and/or pages posted a few days prior to each lecture.

2. In many instances there is a unique pattern of inheritance. Traits disappear and reappear in new ratios. CB 14.3

3. GenotypePhenotype CB 14.6

4. Human blood types AA or AO AB BB or BO OO CB tbl 14.2

5. Looking at the past: If Frank has B blood type, his Dad has A blood type, And his Mom has B blood type… Should Frank be worried?

6. Mom=B blood BB or BO Dad=A blood AA or AO Gametes all B / 50% B and 50% O all A / 50% A and 50% O possible genotypes Frank can be BO = B blood …no worries

7. We can also predict the future Fig 2.12

8. Mom = ABDad = AB Inheritance of blood types

9. Mom = ABDad = AB Gametes:A or B Inheritance of blood types

10. Mom = ABDad = AB Gametes: A or B AA ABBB AB Chance of each phenotype for each offspring 25% AA 50% AB 25% BB Mom Dad Inheritance of blood types

11. CB 14.7 Testcross: determining dominant/ recessive and zygosity

12. CB 5.21 Sickle-cell anemia is caused by a point mutation

13. Sickled and normal red blood cells

14. Mom = HSDad = HS H or S HH HSSS HS possible offspring 75% Normal 25% Sickle-cell Mom Dad S=sickle-cell H=normal Sickle-Cell Anemia: A dominant or recessive allele?

15. Coincidence of malaria and sickle-cell anemia CB 23.13

16. Mom = HSDad = HS H or S HH HSSS HS possible offspring Oxygen transport: 75% Normal 25% Sickle-cell Malaria resistance: 75% resistant 25% susceptible Mom Dad Sickle-Cell Anemia: A dominant or recessive allele? S=sickle-cell H=normal

17. Variation in Peas

18. Phenotype Genotype CB 14.8

19. The inheritance of genes on different chromo- somes is independent.

20. Y y rR Gene for seed color Gene for seed shape Approximate position of seed color and shape genes in peas Chrom. 1/7Chrom. 7/7

21. CB 15.2 The inheritance of genes on different chromosomes is independent: independent assortment

22. CB 15.2 meiosis I meiosis II

23. CB 15.2 The inheritance of genes on different chromosomes is independent: independent assortment

24. CB 14.8

25. Inheritance can be predicted by probability CB 14.9

26. Probability of a 4= 1/6 Probability of two 4’s in a row= 1/6x1/6=1/36

27. Probability of 3 or 4 = 1/6+1/6= 1/3

28. “and” multiply “or” add

29. Huntington’s Disease D=disease d=normal Neurological disease, symptoms begin around 40 years old.

30. Mom = ddDad = Dd d or d D or d Dd dd possible offspring 50% Huntington’s 50% Normal Mom Dad Huntington’s Disease D=disease d=normal

31. Two different people: One with Huntington’s disease = Dd Hh One without Huntington’s disease = dd Hh mate. What is the probability that their offspring will have Huntington’s disease and sickle cell anemia? (Dd hh)

32. Two people: One with Huntington’s disease = Dd Hh One without Huntington’s disease = dd Hh mate. What is the probability that their offspring will have Huntington’s disease and sickle cell anemia? Dd hh Probability of each outcome: Probability of Dd (Ddxdd) =.5 Probability of hh (HhxHh) =.25

33. Two people: One with Huntington’s disease = Dd Hh One without Huntington’s disease = dd Hh mate. What is the probability that their offspring will have Huntington’s disease and sickle cell anemia? Dd hh Probability of each outcome: Probability of Dd (Ddxdd) =.5 Probability of hh (HhxHh) =.25 Multiply both probabilities.25 X.5 = 12.5% chance Dd hh offspring

34. CB 14.11 Many traits are coded for by more than one gene.

35. Eye color: One trait controlled by multiple genes

36. Lectures posted online after lecture. Textbook sections and/or pages posted a few days prior to each lecture.