1. Renaissance® Brain Module Sales Presentation

2. Renaissance Value in Brain Surgery 2 Improves patient care:  Small, frameless platform may improve patient comfort and increase freedom of movement during the procedure Enhances surgeon capabilities:  3D pre-planning software  360 degree working volume allows for operation of multiple trajectories with ease Enhances hospital offering:  Differentiates brain program  Attracts new surgeons and new patients  May improve OR efficiencies  Can utilize Renaissance in both spine and brain procedures Applications:  Deep Brain Stimulation  Brain biopsies

3. 3 Planning Software Workstation Guidance Unit Renaissance Brain Module Pre-operative Surgical Accessories Set Intra-operative Surgical Accessories Set Disposable Kit

4. Renaissance Brain Module How it Works 4 Step 1: Plan Step 2: Mount Step 3: Fuse Step 4: Operate

5. Step 1: Plan 5  A Renaissance brain procedure begins with a pre-operative MRI scan of the patient.  The scan is uploaded into Renaissance’s pre- operative 3D software for surgeons to plan the optimal trajectories prior to the procedure.

6. Step 2: Mount 6  The software identifies optimal locations to place the base for mounting the platform.  The surgeon selects one of the optimal locations and mounts the base to the patient’s skull with three points of fixation using local anesthesia. Patient benefits:  Less invasive than stereotactic frame  May improve patient comfort and increase freedom of movement during the procedure

7. Step 3: Fuse 7  The marker is attached to the platform and then a CT scan is taken.  The CT scan is then fused with the pre-operative MRI scan to enable execution of the surgical plan.

8. Step 4: Operate 8  After the scans are fused, the guidance unit is attached to the base.  The surgeon can then send the guidance unit to the planned trajectories. Surgeon benefit:  Full 360 degree working volume to operate multiple trajectories with ease

9. Surgeon Experience 9