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Emanuela Branchetti PhD 1, Karianna R. Milewski MD PhD 1, Eric Lai BS 1 Rachana Sainger PhD 1, Paolo Poggio MS 1, Robert C. Gorman, Joseph E. Bavaria MD.

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Presentation on theme: "Emanuela Branchetti PhD 1, Karianna R. Milewski MD PhD 1, Eric Lai BS 1 Rachana Sainger PhD 1, Paolo Poggio MS 1, Robert C. Gorman, Joseph E. Bavaria MD."— Presentation transcript:

1 Emanuela Branchetti PhD 1, Karianna R. Milewski MD PhD 1, Eric Lai BS 1 Rachana Sainger PhD 1, Paolo Poggio MS 1, Robert C. Gorman, Joseph E. Bavaria MD 1 and Giovanni Ferrari PhD 1 1 Perelman School of Medicine at University of Pennsylvania, Department of Surgery, Division of Cardiovascular Surgery, Philadelphia, PA CTGF modulates Aortic Vascular Smooth Muscle Cell phenotype and regional tissue homeostasis in Bicuspid Aortic Valve-associated Thoracic Aortic Aneurysms None of the authors have financial interest in this work.

2 PATIENTS ENROLLMENTPATIENTS DEMOGRAPHICS

3 COMPARISON BETWEEN THE AORTIC WALL STRUCTURE OF TAV-C TISSUE AND TAV- AND BAV- AORTOPATHIES.

4 BAV AND TAV ASCENDING AORTA TISSUES WITH AND WITHOUT ANEURYSM SHOW DIFFERENCES IN THE EXPRESSION OF VSMC MARKERS OF PHENOTYPE

5 REGIONAL WALL STRESS DISTRIBUTION IN THE ASCENDING AORTA Modified from : Derek P. Nathan, Chun Xu, Arminder S. Jassar, Joseph H. Gorman III, Ron M. Fairman, Joseph E. Bavaria, Robert C. Gorman, Benjamin M. Jackson. Annals of Thoracic Surgery, October 2011.

6 CTGF IS HIGHLY EXPRESSED IN BAV AND TAV TISSUES WITH ANEURYSM. CTGF UP-REGULATES ECM BIOSYNTHESIS AND IS INVOLVED IN THE PHENOTYPIC CHANGE OF AORTIC VSMC IN VITRO.

7 VSMC PHENOTYPE AND CTGF EXPRESSION AT CV AND CX SIDE OF ASCENDING AORTA

8 CTGF INDUCES SYNTHETIC MARKERS OF PHENOTYPE IN VSMC ISOLATED FROM CONTROL AND ANEURISMAL AORTA

9 CONCLUSION AND FUTURE DIRECTIONS Different stress conditions influence VSMC phenotype in BAV aorta. Characterize CTGF as a regulator of VSMC activation and ECM remodeling could serve as a risk stratification tool for BAV- and TAV-associated aortopathies.

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