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Lacie Smith April 22, 2005 Department of Chemistry and Biochemistry Can we fix it! Yes we can! Synthesis of Novel Quorum Sensing molecules
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Bacteria What are bacteria? How do bacteria communicate with one another? Quorum sensing
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Research Questions By making new signaling molecules which resemble the bacterial signaling molecule: Will we be able to interfere with the bacterial communication? Will a damaging agent attach to the signaling molecules so that the bacteria cells will be killed?
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Goal To make several similar compounds with a variation in “R” group
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Methods Overall Scheme:
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Why is this project important? Would benefit the medical, sewage, and marine environment Would offer a new approach in fighting infections
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References Bassler Bonnie: How bacteria talk to each other: regulation of gene expression by quorum sensing, Microbiology 1999, 2:582-587. Brelles-Marino G; Bedmar E.; Journal of Biotechnology 91 2001, 197-209 March J, Bentley W: Quorum sensing and bacterial cross-talk in biotechnology. Biotechnology 2004,15:495-502.
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