1. Tissue Engineering and Regenerative Medicine A Biomedical and Classroom Revolution

2. Tissue Engineering and Regenerative Medicine 1.It’s HOT! 2.It’s Relevant! Everybody is a potential candidate for its application. It helps answer the dreaded question: “Why do we have to learn all this stuff?” It’s multidisciplinary, a new trend in science and education 3. It’s a ‘Burgh Thing!

3. Tissue Engineering Hottest job for 21 st Century Five hottest jobs for the next millennium will be bioengineering/biomedical related.

4. What is Tissue Engineering? Broadly Defined: Tissue Engineering is the development and manipulation of artificial implants, laboratory-grown tissues, genetically engineered cells and/or molecules to replace or support the function of defective or injured parts of the body. Broadly Defined: Tissue Engineering is the development and manipulation of artificial implants, laboratory-grown tissues, genetically engineered cells and/or molecules to replace or support the function of defective or injured parts of the body.

5. No One Discipline Can Tackle the Problem Alone Lee Weiss, Carnegie Mellon

6. Chemical Engineering Molecular Biology Genomics Robotics Computational Biology Materials Science Cell Biology Clinicians Biochemistry Answering TE questions: Old School vs. New School

7. Cells Growth factors Biomimetic extracellular matrix Culture Implant If needed, harvest cells from patient. Guided Tissue Repair Lee Weiss, Carnegie Mellon

8. Variations On a Theme Lee Weiss, Carnegie Mellon

9. Cells Principles of TE & What are we made of? ECM Hormones BloodSupply DefectRegeneration Phil Campbell, Carnegie Mellon

10. Tissue Structure and Function may be Compromised By: 1. Inherent design flaws 2. Hereditary/congenital defects or conditions 3. Disease 4. Trauma 5. Environmental influences/insults 6. Aging

11. Potential Solutions: 1. Surgical or physical manipulation 2. Drug therapy 3. Diet/lifestyle changes 4. Transplants 5. Artificial tissues/organs 6. Gene therapy 7. Tissue Engineering/Regenerative Medicine

12. The ‘burgh, THEN….

13. Same area, NOW…

14. SIS, ECM for repair of soft tissues. Once in place, the matrix, a 3- dimensional scaffold void of cells but with structural and functional proteins still intact, serves to recruit the appropriate cells for tissue remodeling without producing scarring. SIS, ECM for repair of soft tissues. Once in place, the matrix, a 3- dimensional scaffold void of cells but with structural and functional proteins still intact, serves to recruit the appropriate cells for tissue remodeling without producing scarring. Stephen Badylak, PhD, MD, DVM SIS ECM

16. First marine mammal application of ECM tissue repair! Meet Liko, 3-year old dolphin at Dolphin Quest on Hawaii’s Big Island, Liko sustained a tear at base of his dorsal (top) fin -- likely in a game of “chase” with his dolphin cohorts. Thanks to Dr. Badylak’s SIS ECM, Liko has healed and is again performing.

17. Spinal Cord Upper and Lower Jaw Upper and Lower Jaw LimbLimb Retina and Lens An Ultimate Vision for Regenerative Medicine: Complete Tissue Regeneration Adapted from Brockes TailTail HeartHeart The Newt From Dr. Susan Bryant, Univ. of Calif., Irvine Phil Campbell, Carnegie Mellon