3. KEY CONCEPT Blood is a complex tissue that transports materials.

4. red blood cells, white blood cells, and platelets plasma Blood is composed mainly of cells, cell fragments, and plasma. Whole blood is made up of different materials. – Plasma 90% H 2 O- allows for materials to dissolve Concentrations- diffusion into or out of blood Amino acids, glucose, salts, waste, vitamins, hormones – red blood cells – white blood cells – platelets

5. Red Blood Cells Produced from stem cells in bone marrow Lose nucleus as they mature Transport O 2 to cells; remove CO 2 O 2 binds to hemoglobin proteins Dead cells filtered by liver & spleen

6. White blood cells fight pathogens and destroy foreign matter. red blood cell platelet white blood cell

7. Platelets help form clots that control bleeding. platelets fibrin red blood cell white blood cell

8. Proteins on blood cells determine blood type Antigens (markers) – proteins on cell’s surface that identify cells as foreign or natural Antibodies: – proteins from WBCs to attack invaders Will bind to foreign blood types and cause clumps – Float freely in plasma ABO Blood Groups

9. Group A blood A antigens on the surface of your red blood cells and B antibodies in your blood plasma

10. Group B blood B antigens on the surface of your red blood cells and A antibodies in your blood plasma

11. Group AB blood A and B antigens on the surface of your red blood cells and no A or B antibodies at all in your blood plasma

12. Group O blood No A or B antigens on the surface of your red blood cells but you have both A and B antibodies in your blood plasma

13. Rh Factors Rh Factor is another protein found on blood (like the A and B antigens). Rh+ (A+, B+, AB+, O+) – You have the Rh factor protein in blood – Can receive Rh+ or Rh- blood (if you have Rh proteins, but are given blood without it, your body will just make more) Rh- (A-, B-, AB-, O-) – You don’t have the Rh factor protein in blood – Only receive Rh- blood

15. 1) Can this work? Acceptor O- Donor AB-

16. 2) Can this work? Acceptor A+ Donor A-

17. 3) Can this work? Acceptor AB- Donor B-