1. Biozip Suture Group 24 Katie Good and Emily Schaefer Advisors: Bruce Beyer, M.D. Paul King, Ph.D.

2. Problem Statement Requirement Bioabsorbable zip-tie suture Performance Criteria Unidirectional Tension Maintain suture tied and tight Primary Objective Create suture allowing tactility and ease during deep tissue procedures

3. Current Technique Current sutures - application of tension in opposite directions Gynecological procedures - confined areas Difficult to apply tension Suture integrity compromised

4. Our Approach Require tension in one direction Twist tie design Beaded model design Clamp & Fuse

5. Twist Tie Material Considerations Dexon vs. Vicryl Coated vs. Non-coated Monofilament vs. Braided Small gage used during OB-Gyn procedures Material properties after heating Temperature Exposure time

6. Beaded Model Material Shape memory Heat shrink Distance between beads Manufacturing Injection molded 3-D printing Prototype/Testing

7. Testing Our Sutures Instron Tensiometer BlueHill software Ideal for < 2kN 0.4% accuracy Output Tensile strength Elongation Breaking Point Located in VUMC SDRCC

8. Materials Tensile Strength (0-gauge) Polyglactin 910 (Vicryl) ~ 95 N Polyglycolic Acid (Dexon) ~85 N

9. Current Status Fused 4-0 vicryl w. hair straightener Need more samples  optimize fuse Obtain from Hospital Supply Meeting – Dr. DasGupta Learn to use tensiometer Test samples Budget

10. Hemostat 7.25” ~ $19.00 Suture material Vircyl 2-0 ~ $55 – 120 (3 dozen) Dexon 5-0 ~ $192 (dozen) Develop/purchase heating element Hair straighteners ~ $20 – 65 Total ~ $95 – 205

11. Future Work Develop/purchase a heating element Test sutures in SDRCC on tissue/pedicles Dr. Beyer test procedure for ease of application

12. References Bourne, R.B., MD, FRCSC, Bitar, H. MD, Andreae, P.R., BSC, Martin L.M., MB, BS, Finlay, J.B., PhD, & Marquis, F., MD FRCSC (1988). In-vivo comparison of four absorbable sutures: Vicryl, Dexon Plus, Maxon, and PDS. The Canadian Journal of Surgery, 31(1), 43-45. von Fraunhofer, J. A., Storey, R. S., Stone, I. K., & Masterson, B. J. (1985). Tensile strength of suture materials. Journal of Biomedical Materials Research, 19(5), 595-600.