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Delivering clinical research to make patients, and the NHS, better Gynaecology SSG Sept 2015 Research Jenny Forrest, Sub Specialty Lead Wendy Cook, Research.

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Presentation on theme: "Delivering clinical research to make patients, and the NHS, better Gynaecology SSG Sept 2015 Research Jenny Forrest, Sub Specialty Lead Wendy Cook, Research."— Presentation transcript:

1 Delivering clinical research to make patients, and the NHS, better Gynaecology SSG Sept 2015 Research Jenny Forrest, Sub Specialty Lead Wendy Cook, Research Delivery Manager dd/mm/yyyy

2 Gynaecological Tumour Group National Perspective Data from Portfolio ODP – Cut off 21/08/15

3 Gynaecological Tumour Group National Perspective Data from Portfolio ODP – Cut off 21/08/15 Network 2014/20152015/2016 Commercial Non- Commercial TotalRankCommercial Non- Commercial TotalRank East Midlands1265779191013 Eastern35312347131251281 Greater Manchester171051224327304 Kent, Surrey and Sussex183957120 11 North East and North Cumbria12556711017 8 North Thames221041263120215 North West Coast106474101 1112 North West London121071195331342 South London501421922331342 South West Peninsula12941066217197 Thames Valley and South Midlands019 15044 Wessex1582314505 West Midlands24598384111510 West of England4515513115169 Yorkshire and Humber24791037218206

4 Gynaecological Tumour Group Open Studies South West Peninsula Data from Portfolio ODP – Cut off 21/08/15 Study Name UKCRN ID Study Type Study Design Open to New Sites? Total Recruitment DNA Methylation Study1449 Non- Commercial Observati onal Yes (LC)211 ICON8 Trials Programme9812 Non- Commercial Interventi onal Yes80 INTERLACE11775 Non- Commercial Interventi onal Yes8

5 Gynaecological Tumour Group South West Peninsula Sites Data from Portfolio ODP – Cut off 21/08/15 Trust 2014/20152015/2016 Commercial Non- Commercial TotalCommercial Non- Commercial Total Northern Devon Healthcare NHS Trust055000 Plymouth Hospitals NHS Trust042 011 Royal Cornwall Hospitals NHS Trust3811000 Royal Devon and Exeter NHS Foundation Trust2911000 South Devon Healthcare NHS Foundation Trust 549202 Taunton and Somerset NHS Foundation Trust023 016 Yeovil District Hospital NHS Foundation Trust235000

6 Data from CRN SWP Activity Data from EDGE July 2015 AcronymUKCRN IDStudy TypeTrust Investigator Name End DateTargetRecruitment 2015/2016 Recruitment RTT CX.5 (SHAPE):Early Stage 1A2 and 1B1 17481 Non- Commercial Royal Cornwall Hospitals NHS Trust Galaal, Ms Khadra 13-Jul-222800 DESKTOP III11498 Non- Commercial Royal Cornwall Hospitals NHS Trust Galaal, Ms Khadra 31-Aug-18200-42 DNA Methylation Study 1449 Non- Commercial Plymouth Hospitals NHS Trust Hughes, Mr Geoff 31-Dec-17201041439 DNA Methylation Study 1449 Non- Commercial Royal Cornwall Hospitals NHS Trust Lopes, Mr Alberto 31-Dec-1730230-5 DNA Methylation Study 1449 Non- Commercial Taunton and Somerset NHS Foundation Trust Milliken, Mr David 01-Oct-15156616342 GROINSS-V II4971 Non- Commercial Royal Cornwall Hospitals NHS Trust Lopes, Mr Alberto 31-Jan-17500-79 ICON8: Weekly Chemotherapy in Ovarian Cancer 9812 Non- Commercial Northern Devon Healthcare NHS Trust Scatchard, Dr Kate 30-Nov-1425170-54 ICON8: Weekly Chemotherapy in Ovarian Cancer 9812 Non- Commercial Royal Cornwall Hospitals NHS Trust Bailey, Dr Nigel 30-Nov-148110120 ICON8: Weekly Chemotherapy in Ovarian Cancer 9812 Non- Commercial Royal Devon and Exeter NHS Foundation Trust Scatchard, Dr Kate 30-Nov-1412270 54

7 Gynaecological Tumour Group South West Peninsula Open Studies AcronymUKCRN IDStudy TypeTrust Investigator Name End DateTargetRecruitment 2015/2016 Recruitment RTT INTERLACE11775 Non- Commercial Northern Devon Healthcare NHS Trust Forrest, Dr Jennifer 01-Jun-1634058 INTERLACE11775 Non- Commercial Royal Devon and Exeter NHS Foundation Trust Forrest, Dr Jenny 01-Jun-16940-27 NiCCC Trial (BIBF1120) 15374 Non- Commercial Taunton and Somerset NHS Foundation Trust Barlow, Dr Clare 15-Nov-19400-5 PETROC/OV217472 Non- Commercial Plymouth Hospitals NHS Trust Yiannakis, Dr DeINTERLACE 01-Jun-185301 nnis TRIOC12591 Non- Commercial Plymouth Hospitals NHS Trust Yiannakis, Dr Dennis 01-Oct-14500-207 7

8 Gynaecological Tumour Group South West Peninsula Sites Data from Portfolio ODP – Cut off 21/08/15

9 Gynaecological Tumour Group Open Studies Data from Portfolio ODP – Cut off 21/08/15 East Midlands Study Name Total Recruitment DNA Methylation Study34 ENGOT-EN2-DGCG-EORTC-551024 GROINSS-V II41 ICON8 Trials Programme67 INTERLACE14 NCRN - 2597 AEZS-108 vs doxorubicin in 2nd line advanced endometrial ca 5 NCRN - 3244 - Masitinib + Gemcitabine VS Gemcitabine in Ovarian Cancer 1 PARAGON3 TRIOC: TroVax® in Relapsed Ovarian Cancer 1 Eastern Study Name Total Recruitment BriTROC1 - Sample collection study in recurrent HGSOC 28 CORAL: Cancer of the OvaRy Abiraterone triaL 8 CTCR-OV04221 CTCR-OV0513 Diffusion weighted Imaging Study in Cancer of the Ovary (DISCOVAR) 47 DNA Methylation Study77 GROINSS-V II48 ICON8 Trials Programme122 INTERLACE1 METRO-BIBF8 NCRN - 2746 / ARIEL 3 - Rucaparib in platinum-sensitive high-grade gynaecological cancer 1 PARAGON8 PAZOFOS3 Uterine LMS study1

10 Gynaecological Tumour Group Open Studies Data from Portfolio ODP – Cut off 21/08/15 Greater Manchester Study Name Total Recruitment BriTROC1 - Sample collection study in recurrent HGSOC 11 DNA Methylation Study1 GROINSS-V II26 ICON8 Trials Programme107 INTERLACE3 Metformin for endometrial cancer RCT 17 METRO-BIBF7 MIRENA study22 NCRN - 2746 / ARIEL 3 - Rucaparib in platinum- sensitive high-grade gynaecological cancer 4 NCRN - 3244 - Masitinib + Gemcitabine VS Gemcitabine in Ovarian Cancer 1 PARAGON8 PAZOFOS3 TRIOC: TroVax® in Relapsed Ovarian Cancer 2 Kent, Surrey and Sussex Study NameTotal Recruitment DNA Methylation Study33 ENGOT-EN2-DGCG-EORTC- 55102 1 EORTC Quality of Life Module for patients with vulva cancer 8 GROINSS-V II12 ICON8 Trials Programme79 METRO-BIBF4 PARAGON8 TRIOC: TroVax® in Relapsed Ovarian Cancer 5

11 Gynaecological Tumour Group Open Studies Data from Portfolio ODP – Cut off 21/08/15 North East and North Cumbria Study Name Total Recruitment BriTROC1 - Sample collection study in recurrent HGSOC 1 Diffusion weighted Imaging Study in Cancer of the Ovary (DISCOVAR) 3 DNA Methylation Study186 GROINSS-V II7 ICON8 Trials Programme72 INTERLACE2 PARAGON12 North Thames Study Name Total Recruitment BriTROC1 - Sample collection study in recurrent HGSOC 24 DEPICT12 DNA Methylation Study68 GROINSS-V II30 ICON8 Trials Programme130 INTERLACE22 METRO-BIBF11 NCRN - 2746 / ARIEL 3 - Rucaparib in platinum- sensitive high-grade gynaecological cancer 4 Uterine LMS study1

12 Gynaecological Tumour Group Open Studies Data from Portfolio ODP – Cut off 21/08/15 North West Coast Study Name Total Recruitment ICON8 Trials Programme106 INTERLACE2 MAPPING25 METRO-BIBF5 NCRN - 2597 AEZS-108 vs doxorubicin in 2nd line advanced endometrial ca 1 PARAGON9 TRIOC: TroVax® in Relapsed Ovarian Cancer 6 North West London Study Name Total Recruitment BriTROC1 - Sample collection study in recurrent HGSOC 22 CANC - 3792 REFMAL 339: ME-344 with Topotecan in Solid Tumors 2 DEPICT5 Diffusion weighted Imaging Study in Cancer of the Ovary (DISCOVAR) 17 ICON8 Trials Programme70 MAPPING39 NCRN - 2597 AEZS-108 vs doxorubicin in 2nd line advanced endometrial ca 8 NCRN - 2746 / ARIEL 3 - Rucaparib in platinum-sensitive high-grade gynaecological cancer 2 ProGem2 - Acelarin(NUC1031) plus Carboplatin for recurrent ovarian cancer 14 The role of obesity and diabetes in endometrial cancer 31 BriTROC1 - Sample collection study in recurrent HGSOC 22

13 Gynaecological Tumour Group Open Studies Data from Portfolio ODP – Cut off 21/08/15 South London Study NameTotal Recruitment ADC as a Prognostic Biomarker in Cervical Cancer 95 BriTROC1 - Sample collection study in recurrent HGSOC 2 CORAL: Cancer of the OvaRy Abiraterone triaL 14 DEPICT3 Diffusion weighted Imaging Study in Cancer of the Ovary (DISCOVAR) 47 ICON8 Trials Programme72 MAPPING13 METRO-BIBF15 NCRN - 2597 AEZS-108 vs doxorubicin in 2nd line advanced endometrial ca 8 NCRN - 2746 / ARIEL 3 - Rucaparib in platinum-sensitive high-grade gynaecological cancer 5 PARAGON17 PAZOFOS4 Uterine LMS study1 Thames Valley and South Midlands Study Name Total Recruitment ICON8 Trials Programme 35 METRO-BIBF4 PARAGON2 TRIOC: TroVax® in Relapsed Ovarian Cancer 3

14 Gynaecological Tumour Group Open Studies Data from Portfolio ODP – Cut off 21/08/15 Wessex Study Name Total Recruitment DNA Methylation Study 66 ICON8 Trials Programme 23 NCRN - 3244 - Masitinib + Gemcitabine VS Gemcitabine in Ovarian Cancer 3 West Midlands Study Name Total Recruitment BriTROC1 - Sample collection study in recurrent HGSOC 3 DNA Methylation Study1 EPIVIN trial14 GROINSS-V II25 ICON8 Trials Programme155 INTERLACE4 MAPPING5 NCRN - 2597 AEZS-108 vs doxorubicin in 2nd line advanced endometrial ca 5 NCRN - 3244 - Masitinib + Gemcitabine VS Gemcitabine in Ovarian Cancer 2 PARAGON2 ROCkeTS4

15 Gynaecological Tumour Group Open Studies Data from Portfolio ODP – Cut off 21/08/15 West of England Study Name Total Recruitment BriTROC1 - Sample collection study in recurrent HGSOC 4 CORAL: Cancer of the OvaRy Abiraterone triaL 8 DNA Methylation Study77 GROINSS-V II1 ICON8 Trials Programme80 METRO-BIBF5 PARAGON1 TRIOC: TroVax® in Relapsed Ovarian Cancer 3 Yorkshire and Humber Study Name Total Recruitment Actinomycin-D vs Methotrexate for treatment of low risk GTN 4 BriTROC1 - Sample collection study in recurrent HGSOC 11 DNA Methylation Study111 ENGOT-EN2-DGCG-EORTC-551023 GROINSS-V II27 ICON8 Trials Programme68 INTERLACE9 METRO-BIBF2 NCRN - 2597 AEZS-108 vs doxorubicin in 2nd line advanced endometrial ca 2 NCRN - 2746 / ARIEL 3 - Rucaparib in platinum-sensitive high-grade gynaecological cancer 3 PARAGON5 SHAPE - Simple Hysterectomy And Pelvic node dissection in Early cervix cancer 1

16 Division 1- Cancer - Contacts Duncan Wheatley, Clinical Specialty Lead duncan.wheatley@rcht.cornwall.nhs.uk 01872 258312duncan.wheatley@rcht.cornwall.nhs.uk Jenny Forrest, Sub specialty lead jennifer.forrest1@nhs.net 01392 402106 jennifer.forrest1@nhs.net Wendy Cook, Research delivery manager wcook1@nhs.net 01392 406995 wcook1@nhs.net Ann Courtman, Administrator ann.courtman@nhs.net ann.courtman@nhs.net 01392 406966 16


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