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Published byIlene Young Modified over 9 years ago
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Biochemistry Lecture 11
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Common Biochemical Reaction Types
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Electrophiles
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Nucleophiles
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Nucleophilic Substitution
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Nucleophilic Acyl Substiution (Group Transfer Reaction)
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Nucleophilic Addition
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Carbonyl Condensation
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Elimination
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Oxidation and Reduction
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Overview of Energy Metabolism FATS POLYSACCHARIDES PROTEINS Fatty Acids, Glucose and Amino Acids Glycerol other sugars Stage I Digestion Acetyl CoA Stage II Anaerobic TCA cycle CO 2 CoA e- ADP ATP O2O2 Oxidative Phosphorylation Stage III Aerobic
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Principles of Regulation The flow of metabolites through the pathways is regulated to maintain homeostasis Sometimes, the levels of required metabolites must be altered very rapidly –Need to increase the capacity of glycolysis during the action –Need to reduce the capacity of glycolysis after the action –Need to increases the capacity of gluconeogenesis after successful action
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Rates of a Biochemical Reaction Rates of a biochemical reaction depend on many factors Concentration of reactants Activity of the catalyst –Concentration of the enzyme –Intrinsic activity of the enzyme Concentrations of effectors –Allosteric regulators –Competing substrates –pH, ionic environment Temperature
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Reactions Far From Equilibrium are Common Points of Regulation
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