1. Simple molecules <1nm IBM PowerPC 750 TM Microprocessor 7.56mm×8.799mm 6.35×10 6 transistors semiconductor nanocrystal (CdSe) 2nm 10 -10 10 -5 10 -9 10 -7 10 -6 10 -8 10 -4 10 -3 10 -2 m Circuit design Copper wiring width 0.2  m red blood cell ~5  m (SEM) DNA proteins nm bacteria 1  m Nanometer memory element (Lieber) 10 12 bits/cm 2 (1Tbit/cm 2 ) Molecular Machines (Jacobson) Group SOI transistor width 0.12  m diatom 30  m

2. Fab in a Box NanoTectonics All Printed-All Inorganic 3D nm Building Blocks – Seconds Per Layer Ridley et. Al, Science, 286, 746 (1999) Bulthaup et. Al. APL 79(10): 1525 (2001) Molecular Machines (Jacobson) Group Liquid Processed Chips Nanocluster Building Blocks TFT Devices

3. The Desktop Fab NanoMedia Laboratory - MIT

4. Fabrication Figure of Merit F fab = ln (W) / [ a 3  fab E fab ]

5. Molecular Machines Richard P. Feynman (1918-1988) There is Plenty of Room at the Bottom, December 29th, 1959 What I want to talk about is the problem of manipulating and controlling things on a small scale. As soon as I mention this, people tell me about miniaturization, and how far it has progressed today. They tell me about electric motors that are the size of the nail on your small finger. And there is a device on the market, they tell me, by which you can write the Lord's Prayer on the head of a pin. But that's nothing; that's the most primitive, halting step in the direction I intend to discuss. It is a staggeringly small world that is below. In the year 2000, when they look back at this age, they will wonder why it was not until the year 1960 that anybody began seriously to move in this direction….. It is remarkable that given enough time, the synthetic chemist can usually synthesize what they set out to make. http://www.zyvex.com/nanotech/feynman.html

6. Acc. Chem. Res., 30 (10), 393 -401, 1997. 10.1021/ar950199y S0001- 4842(95)00199-3 Copyright © 1997 American Chemical Society Synthetic Supramolecular Chemistry Matthew C. T. Fyfe and J. Fraser Stoddart**

7. BioMolecular Machines Why They Are The Next Revolution - Bypass Moore’s Law: Extremum in Cost / Size / Yield - Combinatorically Interchangeable Parts - Self Replicating

8. Radio Frequency Control of Biomolecular Machines Molecular Machine (Jacobson) Group MIT Media Lab and Center for Bits and Atoms