1. Good morning, have a nice time

2. What’s new about lesions of prostatic gland? By Taghreed Abd El_Sameea Ass. Prof. of pathology Faculty of Medicine Benha University

3. Anatomy of prostatic gland Site of the gland

4. Relation to adjacent organs urinary bladder, prostate and different duct sagittal section

5. Prostatic carcinoma Causes: Genetic: -Dietary: Trans fatsTrans fats -Medication exposure: conversion of testosterone to dihydrotestosteronetestosterone dihydrotestosterone -Viral elements: HPV --precancerous lesions( LGPIN, HGPIN and ASAP)

6. Precancerous lesions in the prostate carcinoma in situ or prostatic intraepithelial neoplasia (PIN) that includes LGPIN, HGPIN and ASAPcarcinoma in situprostatic intraepithelial neoplasia

7. LGPIN, note the irregular spacing of the lining epithelium with nuclear hyperchromasia and more frequent inconspicuous nucleoli

8. Tufting, papillary formations and signet ring patterns (intraluminal signet ring neoplastic cells) confined to a pre- existing gland, as demonstrated by positive basal cell staining in HGPIN

9. HGPIN/ micropapillary and cribriform patterns, note more benign appearing cytology towards center of gland.

10. HGPIN, papillary pattern and mucinous type with flat pattern of growth, note filling the gland by blue mucin

11. Diagnosis of PIN 1- Needle biopsy 2- TURP 3- TRUS

12. Gross pattern of normal prostate versus prostatic carcinoma

13. Ductal adenocarcinoma of the prostate. Papillary type of growth, Cribriform pattern.

14. invasive prostatic adenocarcinoma. The neoplastic cells are arranged in glands around central lumens. Delicate fibrovascular stroma separates the malignant glands. The neoplastic cells have prominent nucleoli and little cytoplasm.

15. Early diagnosis of prostatic carcinoma Engrailed-2 (EN2) in the urine is highly senstiveEngrailed-2 (EN2) Digital rectal examinationrectal examination Ultrasound (US) and Magnetic Resonance Imaging (MRI)

16. Role of tumor markers in diagnosis and follow up in patients with prostatic carcinoma PSA and PAP BCL-2 Ki-67 ERK5

17. Prevention of prostatic caner Medications Two medications which block the conversion of testosterone to dihydrotestosterone, finasteride and dutasteride,. testosteronedihydrotestosteronefinasteride dutasteride Vaccine, under trial Ejaculation frequency may decrease a man's risk of prostate cancer. Diet: fish, Omega-3 fatty acidsOmega-3fatty acids Trans fats may be associated with an increased risk of cancerTrans fats

18. recommendations Starting at age 50 years, (45 years if your brother or father suffered from prostatic lesion before age 65) Engrailed-2 (EN2) in the urineEngrailed-2 (EN2) Digital rectal examination may allow a doctor to detect perepheral zone prostate abnormalities.rectal examination Biopsy.

19. Thanks to all, good bye