1. Today Elements of complex genomes Protein domains and exon shuffling
Origin of novel genes
Alternative splicing
Transposable elements and genome size

2. Protein domains bind antigens in human immunoglobulin
C:\Figures\Chapter19\high-res\Evolution-Fig jpg

3. Evolution and conservation of domains in diverse proteins
C:\Figures\Chapter19\high-res\Evolution-Fig jpg

4. New domains and human cognition

5. Number of paralogs in complete genomes of five species of yeast
C:\Figures\Chapter19\high-res\Evolution-Fig jpg

6. Paralog number and organismal complexity

7. Origin of a new Drosophila gene, jingwei
C:\Figures\Chapter19\high-res\Evolution-Fig jpg

8. Antarctic Notothenoids - a radiation of ‘ice fish’

9. The evolution of AFGP genes of Antarctic notothenioid fishes
C:\Figures\Chapter19\high-res\Evolution-Fig jpg

10. Mechanisms of creating new genes

11. Co-option of an ancient transposable element

12. Abundance of an novel transposable element in coelacanth

13. Identifying cases of alternative splicing
Tall boxes - human
Short boxes - mouse
Genomic sequence (introns and exons)
Shading indicates matches of genomic sequence and ESTs
(white - 1 or 2 database matches; dark - multiple database matches)

14. Drosophila Dscam gene

15. Alterantive splicing in the Drosophila fruitless gene

16. Splice variants control sexual behavior
fruF prevents male-specific splicing
fruM and fru∆tra force male splicing
FruC, control allele

17. The ENCODE project and new view of the gene
Mark B. Gerstein et al. Genome Res. 2007; 17:

18. Genome size variation
C:\Figures\Chapter19\high-res\Evolution-Fig jpg

19. Fractions of genomic DNA

20. Age distribution of human retroelements

21. Classic genomic differences between birds and mammals
Small genomes
Little repetitive DNA
Small introns (?)
Michrochomosomes
High gene density
Large genomes
Abundant repeats
Large introns
Macrochromosomes
Low gene density