1. Drug Coated Balloons for PAD William B. Newton III, MD Assistant Professor of Surgery Department of Vascular and Endovascular Surgery

2. Contents  Introduction  PAD Burden  Anatomy of a Drug Coated Balloon  LUTONIX® 035 Device Overview  Product Offering Procedure Steps  LUTONIX® 035 Treatment Algorithm  LUTONIX® 035 Pre- Clinical Evidence  LEVANT2ClinicalTrial  LEVANT2ClinicalCase Studies  Resources

3. Introduction  DCB available:  LUTONIX® 035 Drug Coated Balloon is the first and ONLY of its kind technology in the U.S. that can advance our treatment algorithm for SFA/Popliteal disease.  Others are in the process of obtaining FDA approval.

4. Peripheral Artery Disease Impact

5. Anatomy of DCB

6. DCB Formulation

7. DCB Development

8. DCB Design

9. DCD Carriers

10. DCB Coating Integrity

12. DCB Coating Uniformity

14. DCB Mechanism of Action

15. DCB Preclinical Safety Data

17. DCB: LEVANT 2

26. DCB IFU

27. DCB Offering

28. DCB Treatment Considerations

29. DCB Procedure

30. DCB Procedure Steps

33. DCB: Antiplatelet Regimen

34. DCB: Summary

35. DCB: Case 1

36. DCB: Case 2

37. DCB: Case 3

38. DCB: Case 4

39. DCB: Case 5

40. DCB: Case 6

41. DCB: Questions ??