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The Bernard M. Gordon Center for Subsurface Sensing and Imaging Systems  Prof. Charles A. DiMarzio  Northeastern University Portable Skin Cancer Microscope.

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Presentation on theme: "The Bernard M. Gordon Center for Subsurface Sensing and Imaging Systems  Prof. Charles A. DiMarzio  Northeastern University Portable Skin Cancer Microscope."— Presentation transcript:

1 The Bernard M. Gordon Center for Subsurface Sensing and Imaging Systems  Prof. Charles A. DiMarzio  Northeastern University Portable Skin Cancer Microscope Product Development This work was supported by in part by the Gordon Center for Subsurface Sensing and Imaging Systems, under the Engineering Research Centers Program of the National Science Foundation (Award # EEC-9986821). 5 Million Biopsies for 1 Million Cancers!

2 Example of Current Confocal Microscope Technology 25  m - VivaScope 1000 - Sub-Cellular Resolution - Imaging to DE Junction - Large Package - Limited Flexibility

3 Next Generation: NU Work  Get the Light from the Microscope to the Patient and Back  Make the Microscope Smaller

4 Articulated Arm and Endoscope Gustavo Herrera (BS 2003, MS 2005), Milind Rajadhyaksha, Gary Peterson (BS, 2007) Multiple Wavelengths: 532 nm, 830 nm, and 1064 nm √ See Poster (capstone)

5 Theta Line Scanner Peter Dwyer (BS 1989, MS 1997, Ph.D. 2005), Milind Rajadhyaksha Confocal in One Direction, but Not in the Other for Greater Speed. Bistatic for Improved Sectioning. -Dwyer, Peter J., Charles A. DiMarzio, James M. Zavislan, William J. Fox, and Milind Rajadhyaksha, “Confocal Reflectance Theta Line--Scanning for Imaging Human Skin in vivo,” Optics Letters, 2006. -Dwyer, P. J., C. A. DiMarzio, and M. Rajadhyaksha, ``Confocal theta line-scanning microscope for imaging human tissues,”Appl. Opt. 46, 1 April 2007. Pp. 1843-1851.

6 Dual Wedge Confocal Microscope Initial Development P1P1 P2P2 αα θ1θ1 θ1θ1 θ2θ2 Bill Warger (MS 2005, Ph.D. Candidate), and Many Undergraduate Students (Capstone Design Winner in 2004) √ See Poster

7 Dual Wedge Confocal Microscope Recent Work 100 µm Upgraded Acquisition System to Achieve Integration time in Seconds rather than Minutes. Operational Goal is 1/5 Second Imaging of Business Card and Plant Material Shows Sectioning and Resolution √ See Poster Design Goal

8 Dual-Wedge Cofocal Microscope Product Development Plan  Submit Proposals  NIH STTR (Close Score)  R01 “Industry-University Partnerships... Imaging for Cancer Investigations”  Submit Paper on Resolution (Done)  Demonstrate Skin Imaging with Sub- Cellular Sectioning and Resolution  Develop Intermediate Generation System (Gordon Fellowship?)  Demonstrate Feasibility, and then Design Hand-Held Instrument

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