1. Treatment of urinary tract infections
Prof. Hanan Habib

2. Goal
To eradicate the offending organisms from the urinary bladder tissue.
The main treatment of UTI is by antibiotics.

3. Choice of antibiotic depends on:
Whether infection is complicated or uncomplicated.
Whether infection is primary or recurrent.
Type of patient : pregnant women ,children , hospitalized patients , diabetic patients Bacterial count.
Presence of symptoms.

4. Uncomplicated UTI Low-risk patient (woman) for recurrent infection.
3-days antibiotic without urine test.
Cure rate 94%.
If E.coli <20% resistant to ampicillin and TMP-SMX
Nitrofurantoin 100mg BID for five days
Or Fosfomycin 3gm Po once + pyridium

5. Choice of antibiotic depend on susceptibility pattern ,include:
Amoxicillin ( with or without clavulanate)
Cephlosporins ( first or second generation)
TMP-SMX
Nitrofurantoin ( long term use)
Fluoroquinolone ( ciprofloxacin or norfloxacin)
(not for pregnant women or children) ,first
choice if other antibiotics are resistant.

6. Complicated Cystitis
Ciprofloxacin for days is better choice then others.

7. Relapsing infection
Caused by treatment failure or structural abnormalities or abscesses.
Antibiotics used as initial infection
Treatment for days.

8. Recurrent infections
Patients with two or more symptomatic UTIs within 6 months or 3 or more over a year.
Need preventive therapy
Antibiotic taken as soon as symptoms develop.
If infection occurs less than twice a year, a clean catch urine test should be taken for culture and treated as initial attack for 3 days.

9. When to consult the doctor ?
If symptoms persist
A change in symptoms
Pregnant women
Three or more infections per year
Impaired immune system
Previous kidney infections
Structural abnormalities of urinary tract
H/O infection with resistant bacteria

10. Postcoital antibiotics
If recurrent UTI related to sexual activity, and episodes recur more than 2 times within 6 months
A single preventive dose taken immediately after intercourse
Antibiotics include: TMP-SMX, Cephalexin or ciprofloxacin

11. Prophylactic antibiotics
Optional for patients who do not respond to other measures.
Reduces recurrence by up to 95%
Low dose antibiotic taken continuously for 6 months or longer, it includes :
TMP-SMX, Nitrofurantoin, or Cephalexin
Antibiotic taken at bed time more effective.

12. Uncomplicated pyelonephritis
Patients with fever, chills and flank pain ,but they are healthy non-pregnant not nauseous or vomiting with no signs of kidney involvement.
Always collect urine for culture
Can be treated at home with oral antibiotics for days with one of the followings :
Ciprofloxacin, Ceftriaxone , Aminoglycosides or
TMP-SMX.
First dose may be given by injection
Avoid Nirofurantoin

13. Continue-
A urine culture may be obtained if the patient has persistent after hrs or recurrent symptoms.

14. Moderate to sever pyelonephritis
Patients need hospitalization
Antibiotic given by IV route for 3-5 days until
symptoms relieved for hrs.
Ciprofloxacin or ceftriaxone for days
If fever and back pain continue after 72 hrs of antibiotic, imaging tests indicated to exclude abscesses, obstruction or other abnormality.

15. Chronic pyelonephritis
Those patients need long-term antibiotic treatment even during periods when they have no symptoms.

16. Treatment of specific populations
Pregnant women
High risk for UTI and complications
Should be screened for UTI
Antibiotics during pregnancy include:
Amoxicillin, ampicillin, cephalosporins,and nitrofurantoin.
Pregnant women should NOT take quinolones.

17. Drug safety During pregnancy
Avoid Ceftriaxone on day before delivery
Avoid nitrofurantoin and trimethoprim (FA)in the first trimester can lead to birth defects
Avoid near term and hemolytic anemia in G6PD deficiency(0.0004%)
Sulfonamides should be avoided in the last days before delivery because they can increase the level of unbound bilirubin in the neonate
Drug safety — Much of the information regarding the safe use of antibiotics during pregnancy was obtained decades ago, before pregnant women were excluded from drug studies because of concerns about risk to the fetus. Thus, there is little information about the safety of many newer antibiotics in pregnancy.
It is generally accepted that penicillins and cephalosporins (FDA category B) are safe in pregnancy. However, drugs with very high protein binding, such as ceftriaxone, may be inappropriate the day before parturition because of the possibility of bilirubin displacement and subsequent kernicterus.
Nitrofurantoin (FDA category B) and sulfonamides (FDA category B) have been associated with birth defects in a case control study [21]. These findings should be interpreted with caution as multiple comparisons involving small numbers of affected exposed infants may have led by chance to the observed small increase in odds ratios. The safest course is to avoid using nitrofurantoin in the first trimester if another antibiotic that is safe and effective is available. This is discussed further separately. (See "The initial prenatal assessment and routine prenatal care", section on 'Medication use'.)
Nitrofurantoin has also been reported to cause hemolytic anemia in the mother and fetus with G-6PD deficiency [22]. The risk of hemolytic anemia is estimated to be only percent of cases, but its use should be avoided near term for this reason [23,24].
Sulfonamides should be avoided in the last days before delivery because they can increase the level of unbound bilirubin in the neonate, although kernicterus related solely to in utero sulfonamide exposure has never been reported.
Trimethoprim (FDA category C) is generally avoided in the first trimester because it is a folic acid antagonist, has caused abnormal embryo development in experimental animals, and some case control studies have reported a possible association with a variety of birth defects [21]. However, it is not a proven teratogen in humans. Women are routinely prescribed folic acid supplementation during pregnancy; this may be particularly important in those who are taking trimethoprim. Additional evaluation of the safety of trimethoprim in human pregnancy is needed. The safest course is to avoid using trimethoprim in the first trimester if another antibiotic that is safe and effective is available.
Fosfomycin (FDA category B) is considered safe in pregnancy [25].
Fluoroquinolones (FDA category C) and tetracyclines (FDA category D) are contraindicated during pregnancy.
Use of antibiotics in pregnancy is discussed further separately. (See "The initial prenatal assessment and routine prenatal care", section on 'Medication use'.)

18. Pregnant women with asymptomatic bacteriuria ( evidence of infection but no symptoms) have 30% risk for acute pyelonephritis in the second or third trimester.
Screening and 3-5 days antibiotic needed.
For uncomplicated UTI, need 7-10 days antibiotic treatment.

19. Diabetic patients Have more frequent and more sever UTIs.
Treated for days antibiotics even patients with uncomplicated infections.

20. Urethritis in men Require 7days regimen of Doxycycline.
A single dose Azithromycin may be effective but not recommended to avoid spread to the prostate gland.
Patients should also be tested for accompanying STD.

21. Children with UTI Usually treated with TMP-SMX or Cephalexin.
Sometimes given as IV.
Gentamicin may be recommended as resistance to cephalexin is increasing.

22. Vesicoureteric reflux ( VUR)
Common in children with UTI
Can lead to pyelonephritis and kidney damage.
Long-term antibiotic + surgery used to correct VUR and prevent infections.
Acute kidney infection : use Cefixime (Suprax) or Gentamicin in a one daily dose. Oral antibiotic then follows IV.

24. Management of catheter-induced UTI
Very common
Preventive measures important
Catheter should not be used unless absolutely necessary and they should be removed as soon as possible.

26. Intermittent use of catheters
If catheter required for long-periods ,it is best to be used intermittently.
May be replaced every 2 weeks to reduce risk of infection and irrigating bladder with antibiotics between replacements
Daily hygiene and use of closed system to prevent infection.

27. Catheter induced infections
Catheterized patients who develop UTI with symptoms or at risk for sepsis should be treated for each episode with antibiotics and catheter should be removed, if possible.
Associated organisms are constantly changing.
May be multiple species of bacteria.

28. continue-
Antibiotic use for prophylaxis is rarely recommended since high bacterial counts present and patients do not develop symptomatic UTI.
ANTIBIOTIC THERAPY HAS LITTLE BENEFIT IF THE CATHETER IS TO REMAIN IN PLACE FOR LONG PERIOD.