Presentation is loading. Please wait.

Presentation is loading. Please wait.

Vasculogenesis and angiogenesis Integrins in vasculature and KO phenotypes Growth Factor Receptors signaling and vasculature phenotypes VEGFR Tip cells.

Similar presentations


Presentation on theme: "Vasculogenesis and angiogenesis Integrins in vasculature and KO phenotypes Growth Factor Receptors signaling and vasculature phenotypes VEGFR Tip cells."— Presentation transcript:

1 Vasculogenesis and angiogenesis Integrins in vasculature and KO phenotypes Growth Factor Receptors signaling and vasculature phenotypes VEGFR Tip cells VEGF, Notch

2 Vasculogesis and angiogenesis in vertebrates

3 Models Intussuseptive angiogenesis (tissues as muscle, often blood flow dependent etc.)

4 Angiogenesis is a dynamic and context determined process

5 Examples of vascular defects

6 Integrins in the vasculature

7 L1CAM A7Lm68% embryonic lethal hemorrgaged E10-14.5 SM cells

8 Integrin inhibitors and RTK agonistic interactions (Kaan)

9 Angiopoitins, Tie1 and Tie2 receptor

10 PDGF RTK signaling

11 VEGF RTK signaling

12

13 VEGFR3 at tips cells

14

15 Signaling in sprouting tip cells

16 Delta-Notch signaling

17

18

19 Sema3 inhibits integrin function. Normal angiogenesis… semaphorins

20

21

22

23 Mouse models affecting TGFbeta signaling

24

25 Haemodynamics affect vascular remodelling example

26 Pixt2 KO phenotypes in 6th BAA Occlusion of right BAAs results in Persistence of left 6 BAA

27

28


Download ppt "Vasculogenesis and angiogenesis Integrins in vasculature and KO phenotypes Growth Factor Receptors signaling and vasculature phenotypes VEGFR Tip cells."

Similar presentations


Ads by Google