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Heterotopic Ossification: Basic-Science Principles and Clinical Correlates by Kavitha Ranganathan, Shawn Loder, Shailesh Agarwal, Victor W. Wong, Jonathan.

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Presentation on theme: "Heterotopic Ossification: Basic-Science Principles and Clinical Correlates by Kavitha Ranganathan, Shawn Loder, Shailesh Agarwal, Victor W. Wong, Jonathan."— Presentation transcript:

1 Heterotopic Ossification: Basic-Science Principles and Clinical Correlates by Kavitha Ranganathan, Shawn Loder, Shailesh Agarwal, Victor W. Wong, Jonathan Forsberg, Thomas A. Davis, Stewart Wang, Aaron W. James, and Benjamin Levi J Bone Joint Surg Am Volume 97(13):1101-1111 July 1, 2015 ©2015 by The Journal of Bone and Joint Surgery, Inc.

2 Histopathologic evidence of heterotopic ossification (hematoxylin and eosin). Kavitha Ranganathan et al. J Bone Joint Surg Am 2015;97:1101-1111 ©2015 by The Journal of Bone and Joint Surgery, Inc.

3 The common locations of heterotopic ossification are indicated according to the mechanism of injury. Kavitha Ranganathan et al. J Bone Joint Surg Am 2015;97:1101-1111 ©2015 by The Journal of Bone and Joint Surgery, Inc.

4 Burn injury and the resulting hypoxic environment increase HIF-1α production, which leads to angiogenesis as a result of increased levels of VEGF. Angiogenesis is an important step in the process of bone formation. Kavitha Ranganathan et al. J Bone Joint Surg Am 2015;97:1101-1111 ©2015 by The Journal of Bone and Joint Surgery, Inc.

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