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Antigen Presenting Cells

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Presentation on theme: "Antigen Presenting Cells"— Presentation transcript:

1 Antigen Presenting Cells
Antigens: types and features Principles of antigen recognition by T and B cells Antigen Presenting Cells

2 ANTIGENS

3 DEFINITIONS Antigen Immunogen Hapten Carrier
Epitope or antigenic determinant

4 ANTIGEN Molecule that binds antibody or T cell receptor IMUNOGEN antigen that induce immune response

5 IMMUNOGENICITY Depends on characteristics of the immunogene
biological system route of administration

6 IMUNOGENICITY characteristics of the immunogene
Phylogenetic distance Molecular size Chemical composition and heterogeneity proteins > carbohydrates, lipides, nucleic acids Physical appearance particulated > soluble denatured > native

7 IMUNOGENICITY characteristics of the biological system
Genetic bacground species individual Age

8 IMUNOGENICITY administration of the antigen
amount optimal route subcutaneous > intravenous > peroral adjuvant substancee that stimulates immune response to the antigen

9 HAPTEN small molecule that can not elicit an immune response by itself. It can elicit an immune response only when attached to a large molecule – carrier. CARRIER Macromolecule that enables induction of immune response directed to the attached hapten.

10 ANTIGENIC DETERIMINANTE or EPITOPE
Part of the antigen that binds specific antibody or T-cell receptor Antigenic determinantes of the proteins linear conformational

11 conformational determinante
aminoacid linear determinant

12 Principles of antigen recognition by T- and B-lymphocytes

13 Antigens recognized by B-lymphocytes are
Proteins (linear and conformational determinants), carbohydrates, nucleic acids etc. Native and processed Soluble and membrane Antigens recognized by T-lymphocytes are Peptides Linear determinants On the cell membrane within groove of self MHC molecule

14 ANTIGEN-PRESENTING CELLS

15 Figure 8-14

16 Nobel prize for medicine 2011
Dendritc cells Ralph Steinman Nobel prize for medicine 2011

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