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Antigen Presenting Cells
Antigens: types and features Principles of antigen recognition by T and B cells Antigen Presenting Cells
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ANTIGENS
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DEFINITIONS Antigen Immunogen Hapten Carrier
Epitope or antigenic determinant
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ANTIGEN Molecule that binds antibody or T cell receptor IMUNOGEN antigen that induce immune response
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IMMUNOGENICITY Depends on characteristics of the immunogene
biological system route of administration
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IMUNOGENICITY characteristics of the immunogene
Phylogenetic distance Molecular size Chemical composition and heterogeneity proteins > carbohydrates, lipides, nucleic acids Physical appearance particulated > soluble denatured > native
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IMUNOGENICITY characteristics of the biological system
Genetic bacground species individual Age
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IMUNOGENICITY administration of the antigen
amount optimal route subcutaneous > intravenous > peroral adjuvant substancee that stimulates immune response to the antigen
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HAPTEN small molecule that can not elicit an immune response by itself. It can elicit an immune response only when attached to a large molecule – carrier. CARRIER Macromolecule that enables induction of immune response directed to the attached hapten.
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ANTIGENIC DETERIMINANTE or EPITOPE
Part of the antigen that binds specific antibody or T-cell receptor Antigenic determinantes of the proteins linear conformational
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conformational determinante
aminoacid linear determinant
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Principles of antigen recognition by T- and B-lymphocytes
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Antigens recognized by B-lymphocytes are
Proteins (linear and conformational determinants), carbohydrates, nucleic acids etc. Native and processed Soluble and membrane Antigens recognized by T-lymphocytes are Peptides Linear determinants On the cell membrane within groove of self MHC molecule
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ANTIGEN-PRESENTING CELLS
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Figure 8-14
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Nobel prize for medicine 2011
Dendritc cells Ralph Steinman Nobel prize for medicine 2011
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