1. C a p a 1
Universidade de São Paulo
Faculdade de Filosofia Ciencias e Letras de Ribeirão Preto
Departamento de Química
Voltammetric detection of LSD using a chemically modified carbon paste electrode with Schiff base complex
Marcelo Firmino de Oliveira

2. Farmaceutical identifiers
Drug analysis by american CSIs and Brazilian Federal Police
Class A
Class B
Class C
FTIR CE
Spot tests MS GC
fluorescence
H-RMN
TLC
Immunological assay
Raman
HPLC
Melting point
Optical microscopy
UV-Vis
Farmaceutical identifiers
A+A
A+B
A+C
B+B+B
B+B+C
PS: no electrochemical methods cited

3. Cell, electrodes and expected results in voltammetry

4. Example of electrochemical analysis in forensic chemistry:
Cocaine
(SWV: LOD of 1nmol/L)
V. Pavlova et al. / Analytica Chimica Acta 512 (2004) 49–56

5. LSD 1938 – Dr. Albert Hofmann Lysergic acid + diethylamide
d-LSD
d-iso-LSD
l-iso-LSD
l-LSD
1938 – Dr. Albert Hofmann
Lysergic acid + diethylamide
Actuation: CNS
hallucinations;
euphoria;
panic;
confusion;
psychotic episodes.

6. Chemical modifier Schiff Bases: 1864 – Hugo Schiff
Amine + Aldehyde/Ketone
applicability :
antimicrobial
Fungicide
Herbicide
Anticancer
Complexation with metallic centers: UO22+

7. OBJECTIVES
Apply the complex [UO2(Ac-ophen)]·H2O as carbon paste electrode modifier;
Voltammetric detection and quantification of LSD.

8. Experimental
40%
40%
20% CV
SWV
DPV
KCl 0.1M

9. Results
Standard addition – SWV
Frequency: 10 Hz
Amplitude: 800 mV

10. Standard addition - DPV
Amplitude: 800mV
pulse time: 40ms

11. Voltammetric techniqueSD
(μA) m
(μA L μmol-1)
LOD
(μmol L-1)
LOQ
SWV
0.992
1.79x10-2
1.75x10-1
0.31
1.02
DPV
0.984
2.63x10-2
1.52x10-1
0.52
1.73

12. CONCLUSIONS A new transductor for LSD analysis;
Detection and quantification of LSD μmol L-1 range;
Good stability for the proposed CM-CPE in water.
Thank you