1. Animal Circulatory and Respiratory Systems Chapter 42

2. Internal Transport Gastrovascular cavity makes circulatory system unnecessaryGastrovascular cavity makes circulatory system unnecessary Open and closed circulatory systems What are the limits an open circulatory system places on an organism? What is the difference between an artery and a vein? Arteries carry blood away from the heart Veins bring blood back to the heart

3. Why do veins have valves and arteries do not? Veins move blood against gravity without benefit of the heart contraction Blood flow: –Heart  arteries  arterioles  capillaries  venules  veins  heart Which chamber of the heart receives the blood? Which chamber pumps the blood?

4. Vertebrate Circulatory Evolution Fish have 2 chambered heart, one beat circuit: –1 atrium1 atrium –1 ventricle1 ventricle Amphibians have 3 chambered heart: –2 atria2 atria –1 ventricle1 ventricle Reptiles have 3 – 4 chambered heart: –Septum keeps 2 parts of ventricles separate Mammals and birds have 4 chambered heart!

10. The Heart Cardiac muscle Atria have thin walls Ventricles have thick and powerful walls Systole = ventricular contraction blood is pumped Diastole = ventricular filling Lub dub = heart sounds opening and closing of the valves –Lub = contraction of ventricles (AV closing) –Dub = blood recoiling against SL valves Heart murmur = valve defect

11. CO = cardiac output ; –Volume of blood pumped/ minute (avg: 75ml x 70 bpm = 5.25 L/min) SV = stroke volume: –Amount of blood pumped by L ventricle/contraction CO is effected by heart rate and SV –During exercise CO ↑ 5X Myogenic heart can generate its own electrical stimulus SA node is the pacemaker of the heart –Influenced by antagonistic nerves and hormones

13. Arteries and Veins How do differences between arteries and veins reflect their different functions?How do differences between arteries and veins reflect their different functions? Artery wall is very thick to absorb pulsation from heart Veins are wider in diameter and are not as muscular Veins have valves Capillaries have only single layer of endothelium

14. Blood Pressure The force that blood exerts against vessel walls –Determined by cardiac output, blood volume, and resistance BP is greater in arteries than veins Pulse is measure of BP Exact BP is measured as systolic/diastolic pressuresExact BP is measured as systolic/diastolic pressures Constricted blood vessels have higher BP than dilated vesselsConstricted blood vessels have higher BP than dilated vessels In veins heart has little effect on BP How, then does blood move in veins?

15. Blood Flow Velocity

16. Internal Control of Blood Pressure 1.Baroreceptors in wall of blood vessels detect changes and notify the brain (medulla) 2.If high, cardiac center stimulates parasympathetic nerves (causes ↓HR) and vasomotor center inhibits sympathetic nerves controlling smooth muscle  vasodilation 3.Also, hormones – angiotensin (vasoconstrictor), aldosterone (Na + retention in kidneys) 1.Angiotensin blockers and ACE (angiotensin converting enzyme) inhibitors are high blood pressure meds

17. Blood Flow Through Capillary Beds Typically only 5-10% capillary beds are open at a time. “At rest 15-20% of circulating blood supplies skeletal muscle. During vigorous exercise this increases to 80-85% of cardiac output. Blood is shunted away from major organs such as the kidneys, liver, stomach and intestines. It is then redirected to the skin to promote heat loss” Wilmore JH and Costill DL. (2005) Physiology of Sport and Exercise: 3rd Edition. Champaign, IL: Human Kinetics

18. Capillary Movement of Fluids

19. Lymphatic System Lymphatic system returns lost blood to circulatory system –4 L/day –Returns near jxn vena cava/rt atrium Lymph and plasma similar, except lymph has little protein Lymph nodes filter the lymph Help fight infection Edema = swelling (may be due to obstruction of lymph vessels) -due to inflammation, injury, parasitic infection OR due to protein deficiency

20. Lymphatic Filariasis – caused by parasitic worm that imbeds in lymphatic vessels

23. Blood Cells RBC = erythrocytes –25 trillion, 3 to 4 month lifespan –Biconcave disk ↑gas exchange due to ↑ surface area Lack nucleus, more hemoglobin space Lack mitochondria, don’t use O2 that they carry

24. Blood Cells WBC = leukocytes –Monocytes and neutrophils are phagocytic –Lymphocytes = B and T cells –Spend most of time out of circ. system

25. Blood Cells Platelets –Cellular fragments –Clotting Fibrinogen  fibrin Production (all types) –In marrow pluripotent stem cells –Erythropoietin (hormone) stimulates production when O2 levels low banned performance enhancing drug EPO

31. How can 1 heartbeat circulate blood through 2 capillary beds?

32. What are the advantages and disadvantages of the amphibian circulatory system?

33. Why do endotherms have the greatest need for a 4 chambered heart? Birds and mammals show convergent evolution of 4 chambered heart!