1. CHAPTER 9: Chronic Kidney Disease – Mineral and Bone DisorderKok Lai Sun Ching Chen Hua Fan Kin Sing Rozina Ghazalli Liew Yew Fong Source: 21 st MDTR Report 2013, NRR

2. Table 9.1.1: Phosphate Binder in HD patients, 2004-2013 Year Number of patients Number of patients On CaCO 3 Number on patients on Al(OH) 3 Number of patients on Lanthanum Number of patients on Sevelamer HcI n%n%n%n% 2004 816374089110610000 2005 93508567929810000 2006 11681107759271115000 2007 12907118689257037010 2008 15403141459272086130 2009 179771645492340247100 2010 195091780591270377260 2011 2229620566923005152710 2012 2567123655921206473820 2013 28899267189210072531070 Source: 21 st MDTR Report 2013, NRR

3. Table 9.1.2: Phosphate Binder in PD patients, 2004-2013 Year Numbe r of patient s Number of patients On CaCO 3 Number on patients on Al(OH) 3 Number of patients on Lanthanum Number of patients on Sevelamer HcI n%n%n%n% 2004 18421552842410000 2005 22071862842110000 2006 27872373851415020 2007 35773142888022110 2008 404434958614042100 2009 348229458512078210 2010 38443391884093220 2011 4967428786801764240 2012 5752490285602024240 2013 6513558486402213461 Source: 21 st MDTR Report 2013, NRR

4. Table 9.1.3: Phosphate Binders by Sector in HD patients

5. Source: 21 st MDTR Report 2013, NRR Table 9.2.1: Distribution of corrected serum calcium, HD patients 2004-2013 Year Number of patients MeanSDMedianLQUQ % patients ≥2.1 & ≤2.37mmol/L 2004 75352.30.22.32.22.447 2005 86292.30.22.32.22.449 2006 108802.30.22.32.12.450 2007 122752.20.22.22.12.452 2008 144812.30.22.32.12.453 2009 168582.30.22.32.22.452 2010 186552.30.22.32.22.452 2011 212642.30.22.32.12.453 2012 244222.30.22.32.12.454 2013 274962.30.22.32.12.453

6. Source: 21 st MDTR Report 2013, NRR Figure 9.2.1: Cumulative distribution of corrected serum calcium, HD patients 2004-2013

7. Source: 21 st MDTR Report 2013, NRR Table 9.2.2: Distribution of corrected serum calcium, PD patients 2004-2013 Year Number of patients MeanSDMedianLQUQ %patients ≥2.1 & ≤2.37mmol/L 2004 12762.50.22.52.32.623 2005 13382.40.22.42.32.630 2006 14952.40.22.42.32.538 2007 17482.40.22.42.22.542 2008 20172.40.22.42.32.538 2009 21352.40.22.42.22.539 2010 23012.40.22.42.32.537 2011 24482.40.22.42.32.538 2012 27872.40.22.42.22.542 2013 31592.30.22.32.22.542

8. Source: 21 st MDTR Report 2013, NRR Figure 9.2.2: Cumulative distribution of corrected serum calcium, PD patients 2004-2013

9. Source: 21 st MDTR Report 2013, NRR Table 9.2.3: Distribution of serum phosphate, HD patients 2004-2013 Year Number of patients meanSDMedianLQUQ %patients <0.8 mmol/L %patients ≥0.8&<1.3 mmol/L %patients ≥1.3&<1.8 mmol/L %patients ≥1.8&<2.2 mmol/L %patients ≥2.2 mmol/L 2004 76201.80.51.81.52.2114372523 2005 88331.80.51.71.42.1216382519 2006 111281.80.51.71.42.1117392518 2007 124241.80.51.71.42.1116402518 2008 148771.70.51.71.42117412417 2009 172541.80.51.71.42.1115402618 2010 188801.80.51.71.42.1115402619 2011 216911.80.51.71.42.1115402618 2012 248751.80.51.71.42115412517 2013 281021.80.51.71.42116422517

10. Source: 21 st MDTR Report 2013, NRR Figure 9.2.3: Cumulative distribution of serum phosphate, HD patients 2004-2013

11. Source: 21 st MDTR Report 2013, NRR Table 9.2.4: Distribution of serum phosphate, PD patients 2004-2013 Year Number of patients meanSDMedianLQUQ %patients <0.8 mmol/L %patients ≥0.8&<1.3 mmol/L %patients ≥1.3&<1.8 mmol/L %patients ≥1.8&<2.2 mmol/L %patients >2.2 mmol/L 2004 12781.60.51.61.31.9227392011 2005 13431.60.51.61.31.9226402012 2006 15111.60.51.61.31.9224431912 2007 17571.60.51.61.31.9223441813 2008 20221.60.51.51.31.9227421712 2009 21471.60.51.51.21.9227411812 2010 23031.60.51.51.21.9228401811 2011 24741.60.51.51.31.9227411911 2012 27971.60.51.51.31.9227421811 2013 31621.60.51.51.31.9226431811

12. Source: 21 st MDTR Report 2013, NRR Figure 9.2.4: Cumulative distribution of serum phosphate, PD patients 2004-2013

13. Source: 21 st MDTR Report 2013, NRR Table 9.2.5: Distribution of corrected calcium x phosphate product, HD patients 2004-2013 Year Number of patients meanSDMedianLQUQ % patients with calcium phosphate product: <3.5 mmol 2 /L 2 >3.5 & <4.5 mmol 2 /L 2 >4.5 & <5.5 mmol 2 /L 2 >5.5 mmol 2 /L 2 2004 74144.21.34.13.3532 2215 2005 849541.33.93.24.836322012 2006 1075741.23.83.14.738321911 2007 121723.91.23.83.14.638331910 2008 143633.91.23.83.14.63933199 2009 1672141.23.93.24.736342011 2010 1853541.23.93.24.834 2111 2011 2111441.23.93.24.736342010 2012 2420441.13.83.24.637341910 2013 272833.91.13.83.24.63734199

14. Source: 21 st MDTR Report 2013, NRR Figure 9.2.5: Cumulative distribution of corrected calcium x phosphate product, HD patients 2004-2013

15. Source: 21 st MDTR Report 2013, NRR Table 9.2.6: Distribution of corrected calcium x phosphate product, PD patients 2004-2013 Year Number of patients meanSDMedianLQUQ % patients with calcium phosphate product: <3.5 mmol 2 /L 2 >3.5 & <4.5 mmol 2 /L 2 >4.5 & <5.5 mmol 2 /L 2 >5.5 mmol 2 /L 2 2004 127441.23.834.741301812 2005 13333.91.33.734.643291711 2006 14943.91.23.73.14.64331179 2007 17453.81.23.634.546291510 2008 20093.81.23.634.547281510 2009 21303.81.23.62.94.546291511 2010 22893.81.23.62.94.547291510 2011 24413.81.23.62.94.54629169 2012 27783.81.23.62.94.44829159 2013 31393.71.23.52.94.44929148

16. Source: 21 st MDTR Report 2013, NRR Figure 9.2.6: Cumulative distribution of corrected calcium x phosphate product, PD patients 2004-2013

17. Source: 21 st MDTR Report 2013, NRR Table 9.2.7(a): Variation in corrected median serum calcium level among HD centres 2004-2013 Year Number of centres Min5 th CentileLQMedianUQ95 th CentileMax 2004 2031.92.12.22.32.4 2.5 2005 2301.822.22.32.4 2.5 2006 2761.92.12.22.3 2.42.5 2007 3121.822.2 2.32.42.5 2008 3601.82.12.22.3 2.42.6 2009 4101.52.12.22.3 2.42.6 2010 4411.82.12.22.3 2.42.5 2011 5041.72.12.22.3 2.42.6 2012 54922.12.22.3 2.42.6 2013 60322.12.22.3 2.42.5

18. Source: 21 st MDTR Report 2013, NRR Figure 9.2.7(a): Variation in median serum calcium among HD patients, HD centres 2013

19. Source: 21 st MDTR Report 2013, NRR Table 9.2.8(a): Variation in corrected median serum calcium level among PD centres 2004-2013 Year Number of centres Min5 th CentileLQMedianUQ 95 th Centile Max 2004 182.3 2.4 2.5 2005 192.2 2.4 2.6 2006 222.2 2.32.4 2.52.6 2007 222.2 2.3 2.4 2.5 2008 242.2 2.32.42.52.6 2009 252.22.3 2.4 2.52.6 2010 262.22.3 2.42.5 2011 272.12.3 2.4 2.52.6 2012 282.2 2.3 2.42.52.6 2013 282.2 2.3 2.42.5

20. Source: 21 st MDTR Report 2013, NRR Figure 9.2.8(a): Variation in median serum calcium level among PD patients, PD centres 2013

21. Source: 21 st MDTR Report 2013, NRR Table 9.2.7(b): Proportion of patients with serum calcium 2.1 to 2.37 mmol/L, HD centres, 2004-2013 Year Number of centres Min 5 th Centile LQMedianUQ 95 th Centile Max 2004 2038223847587283 2005 2300213949577091 2006 27613324250597190 2007 312930445260.57293 2008 36082846546173.590 2009 4100294353607386 2010 4410314452617394 2011 5040324654.5627490 2012 5498334755637592 2013 6038334655637390

22. Source: 21 st MDTR Report 2013, NRR Figure 9.2.7(b): Variation in proportion of patients with serum calcium 2.1 to 2.37 mmol/L, HD centres 2013

23. Source: 21 st MDTR Report 2013, NRR Table 9.2.8(b): Proportion of patients with serum calcium 2.1 to 2.37 mmol/L, PD centres Year Number of centres Min 5 th Centile LQMedianUQ95 th CentileMax 2004 1811 1825.52953 2005 1917 25354351 2006 2215253444.5506076 2007 2219243345516263 2008 245153140.5505865 2009 2512132940515863 2010 2613162734.5505657 2011 278133138465863 2012 288931.540.5526071 2013 2810163241.5506070

24. Source: 21 st MDTR Report 2013, NRR Figure 9.2.8(b): Variation in proportion of patients with serum calcium 2.1 to 2.37 mmol/L, PD centres 2013

25. Source: 21 st MDTR Report 2013, NRR Table 9.2.9(a): Variation in median serum phosphate level among HD centres, 2004-2013 Year Number of centres Min 5 th Centile LQMedianUQ 95 th Centile Max 2004 2081.41.51.71.81.92.12.4 2005 2310.81.41.61.71.822.4 2006 28211.51.61.71.822.3 2007 3161.11.41.61.71.822.3 2008 3671.11.41.61.71.822.5 2009 4171.21.51.61.71.822.5 2010 4471.31.51.71.8 2.13 2011 50711.51.61.8 22.4 2012 5611.11.51.61.71.822.6 2013 6061.31.51.61.71.822.4

26. Source: 21 st MDTR Report 2013, NRR Figure 9.2.9(a): Variation in median serum phosphate level among HD patients, HD centres 2013

27. Source: 21 st MDTR Report 2013, NRR Table 9.2.10(a): Variation in median serum phosphate levels among PD centres 2004-2013 Year Number of centres Min 5 th Centile LQMedianUQ 95 th Centile Max 2004 181.3 1.5 1.71.9 2005 191.4 1.5 1.71.9 2006 221.31.41.51.61.71.81.9 2007 221.31.41.51.61.71.81.9 2008 241.21.31.51.61.81.92.1 2009 251.31.41.51.61.71.82.2 2010 261.3 1.41.61.71.9 2011 271.3 1.51.61.71.81.9 2012 281.31.41.51.61.71.8 2013 281.4 1.51.61.71.9

28. Source: 21 st MDTR Report 2013, NRR Figure 9.2.10(a): Variation in median serum phosphate level among PD patients, PD centres 2013

29. Source: 21 st MDTR Report 2013, NRR Table 9.2.9(b): Proportion of patients with serum phosphate 1.13-1.78 mmol/L, HD centres 2004-2013 Year Number of centres Min 5 th Centile LQMedianUQ 95 th Centile Max 2004 20801831.540506892 2005 23112253744546990 2006 28214263846547087 2007 31619273946556792 2008 36710284148566787 2009 4178273946536780 2010 4470243746546774 2011 5079263847546893 2012 5618284047556889 2013 6067274048576884

30. Source: 21 st MDTR Report 2013, NRR Figure 9.2.9(b): Variation in proportion of patients with serum phosphate 1.13-1.78 mmol/L, HD centres 2013

31. Source: 21 st MDTR Report 2013, NRR Table 9.2.10(b): Proportion of patients with serum phosphate 1.13-1.78 mmol/L, PD centres 2004-2013 Year Number of centres Min 5 th Centile LQMedianUQ 95 th Centile Max 2004 1838 4952.56076 2005 1938 46535876 2006 2241444852586668 2007 2241434854.5567379 2008 2430394852.5596671 2009 2520404851566273 2010 2633384551.5606768 2011 2735424751607581 2012 282636485259.56372 2013 28 3645.550566478

32. Source: 21 st MDTR Report 2013, NRR Figure 9.2.10(b): Variation in proportion of patients with serum phosphate 1.13-1.78 mmol/L, PD centres 2013

33. Source: 21 st MDTR Report 2013, NRR Table 9.2.9(c): Proportion of patients with serum phosphate 0.8-1.3 mmol/L, HD centres 2013 Year Number of centres Min 5 th Centile LQMedianUQ 95 th Centile Max 2004 208007.51318.52946 2005 23100815213252 2006 28203915223353 2007 316031016213245 2008 36702915223560 2009 41700914203342 2010 44700814192943 2011 50700914203083 2012 56103814202942 2013 60603914.5203250

34. Source: 21 st MDTR Report 2013, NRR Figure 9.2.9(c): Variation in proportion of patients with serum phosphate 0.8-1.3 mmol/L, HD centres 2013

35. Source: 21 st MDTR Report 2013, NRR Table 9.2.10(c): Proportion of patients with serum phosphate 0.8-1.3 mmol/L, PD centres 2013 Year Number of centres Min 5 th Centile LQMedianUQ 95 th Centile Max 2004 18881725.53248 2005 198816253145 2006 22001319253455 2007 22451520253543 2008 24471723.5 30. 54773 2009 254101925314247 2010 26041523.5324145 2011 27041624324446 2012 28341622323448 2013 285513242936

36. Source: 21 st MDTR Report 2013, NRR Figure 9.2.10(c): Variation in proportion of patients with serum phosphate 0.8-1.3 mmol/L, PD centres 2013

37. Source: 21 st MDTR Report 2013, NRR Table 9.2.11(a): Variation in corrected median calcium x phosphate product HD centres 2004-2013 Year Number of centres Min 5 th Centile LQMedianUQ 95 th Centile Max 2004 2022.93.43.84.14.44.85.6 2005 2232.13.23.63.94.24.85.1 2006 2742.13.23.63.94.14.65.2 2007 3092.53.23.63.84.14.55 2008 3592.73.23.63.84.14.45.7 2009 4062.63.33.73.94.14.66.2 2010 4402.93.43.73.94.24.76.7 2011 50323.33.73.94.24.65.6 2012 5472.73.33.63.84.14.65.7 2013 5972.83.33.63.84.14.65.8

38. Source: 21 st MDTR Report 2013, NRR Figure 9.2.11(a): Variation in median corrected calcium x phosphate product among HD patients, HD centres 2013

39. Source: 21 st MDTR Report 2013, NRR Table 9.2.12(a): Variation in corrected median calcium x phosphate product PD centres 2004-2013 Year Number of centres Min 5 th Centile LQMedianUQ 95 th Centile Max 2004 183.2 3.53.844.4 2005 193.3 3.53.744.3 2006 2233.33.63.744.24.4 2007 223.13.23.53.84.14.3 2008 242.83.13.33.74.14.75.1 2009 253.2 3.53.744.54.8 2010 263.1 3.43.844.54.6 2011 2733.13.43.844.5 2012 283.1 3.53.84.14.34.5 2013 283.2 3.33.73.94.34.5

40. Source: 21 st MDTR Report 2013, NRR Figure 9.2.12(a): Variation in median corrected calcium x phosphate product among PD patients, PD centres 2013

41. Source: 21 st MDTR Report 2013, NRR Table 9.2.11(b): Proportion of patients with corrected calcium x phosphate <4.5 mmol2/L2, HD centres 2004-2013 Year Number of centres Min 5 th Centile LQMedianUQ 95 th Centile Max 2004 202184055637188100 2005 223244558697791100 2006 274304662707992100 2007 309334863738191100 2008 359275064738191100 2009 406204562707989100 2010 440843606976.58995 2011 503184861717990100 2012 547324963728091100 2013 597234864738190100

42. Source: 21 st MDTR Report 2013, NRR Figure 9.2.11(b): Variation in proportion of patients with corrected calcium x phosphate product <4.5 mmol2/L2, HD centres 2013

43. Source: 21 st MDTR Report 2013, NRR Table 9.2.12(b): Proportion of patients with corrected calcium x phosphate <4.5 mmol2/L2, PD 2004-2013 Year Number of centres Min 5 th Centile LQMedianUQ 95 th Centile Max 2004 1854 66737989 2005 1953 67747885 2006 2253576770.5798896 2007 2251576473808898 2008 2440416271.5829197 2009 25404965767986 2010 2649506874808889 2011 2748506473809295 2012 2848586771849091 2013 2850616573838994

44. Source: 21 st MDTR Report 2013, NRR Figure 9.2.12(b): Variation in proportion of patients with corrected calcium x phosphate product <4.5 mmol2/L2, PD centres, 2013

45. Source: 21 st MDTR Report 2013, NRR Table 9.3.1(a): Treatment of hyperparathyroidism in HD patients, 2004-2013 Year Number of patients Number of patients on calcitriol Number of patients on Paricalcitol Number of patients had Parathyroidectomy n%n % n % 2004 81632028250000 2005 935025562700430 2006 116813822333401521 2007 129074950386001811 2008 154036346416401741 2009 179777790439211671 2010 1950990784715711701 2011 22296107624813911771 2012 25671118054626612641 2013 28899138584821113151

46. Source: 21 st MDTR Report 2013, NRR Table 9.3.1(b): Treatment of hyperparathyroidism in PD patients, 2004-2013 Year Number of patients Number of patients on calcitriol Number of patients on Paricalcitol Number of Patients had Parathyroidectomy n%n % n % 2004 1842439240000 2005 2207534240080 2006 27876582460271 2007 357710332990221 2008 404412103080261 2009 348212323550160 2010 384415314040110 2011 4967184137240210 2012 5752216238621481 2013 6513220234280381

47. Source: 21 st MDTR Report 2013, NRR Table 9.3.2(a): Distribution of iPTH, HD patient 2004-2013 Year Number of Patients MeanSDMedianLQUQ Percent patients with iPTH: <150 pg/ml >150 & >300 pg/ml >300 & >500 pg/ml >500 pg/ml 2004 4747212.1325.674.322.6257.565131013 2005 5825221.6312.583.826.529761141114 2006 7743219.2307.2882929261141113 2007 9151245.8332.710530.4335.558151216 2008 10754260.8330.91273636154171317 2009 12647269.4337.21404036752181317 2010 14364235.6319.398.530.5319.858151115 2011 16411223.3312.487.129.2304.361141214 2012 18943291.5340.216746.6410.448181519 2013 21390231.9315.29833.7309.359151114

48. Source: 21 st MDTR Report 2013, NRR Figure 9.3.2(a): Cumulative distribution of iPTH, HD 2004-2013

49. Source: 21 st MDTR Report 2013, NRR Table 9.3.2(b): Distribution of iPTH, diabetic HD patients 2004-2013 Year Number of Patients MeanSDMedianLQUQ Percent patients with iPTH: <150 pg/ml >150 & >300 pg/ml >300 & >500 pg/ml >500 pg/ml 2004 1532111.4193.63814114.4801055 2005 2107149.5246.147.416.1170.5721288 2006 3069155253.25420.8173.5721287 2007 3682183.1267.470.623235.5661410 2008 4595208.8275.398.929.1286.5591712 2009 5646218.3284111.233.7292571812 2010 6574189.6268.97526255.864151110 2011 7552182.7264.566.924.6241.5661310 2012 8823249.7290.614542358511915 2013 9890197.8269.582.531.1266.6631511

50. Source: 21 st MDTR Report 2013, NRR Figure 9.3.2(b): Cumulative distribution of iPTH, diabetic HD patients 2004-2013

51. Source: 21 st MDTR Report 2013, NRR Table 9.3.2(c): Distribution of iPTH, non-diabetic HD patients 2004-2013 Year Number of Patients MeanSDMedianLQUQ Percent patients with iPTH: <150 pg/ml >150 & >300 pg/ml >300 & >500 pg/ml >500 pg/ml 2004 3215260.1362.7102.530.533958141117 2005 3718262.5337.8114.335.5364.555151317 2006 4674261.3331.4122.739362.554161317 2007 5469288364.2135.238.840352151319 2008 6159299.6362.215542.741849161421 2009 7001310.6369.6170.547.8433.547171421 2010 7790274.5351.6126.936.538654151219 2011 8859258344.3108.134.7357.556141317 2012 10120327.9374.3189.851.2469.145171523 2013 11500261.2347.211437352.356151217

52. Source: 21 st MDTR Report 2013, NRR Figure 9.3.2(c): Cumulative distribution of iPTH, non- diabetic HD patients 2004-2013

53. Source: 21 st MDTR Report 2013, NRR Table 9.3.3(a): Distribution of iPTH, PD patients 2004-2013 Year Number of Patients MeanSDMedianLQUQ Percent patients with iPTH: <150 pg/ml >150 & >300 pg/ml >300 & >500 pg/ml >500 pg/ml 2004 1115216.4302.910539.526060191011 2005 1071247.1306.4125.33935254181315 2006 1265224.6271.912841.531854201412 2007 1436248.4297.1152.551332.850221514 2008 1608264.2295.3170.357.3357.746221815 2009 1824270.6292.7174.267.8381452216 2010 1905261.5294.816351371482016 2011 2040249.3282.7160.350343.348231614 2012 2264274.4292.5188.464384.343221915 2013 2600213.5251.313452284.25324149

54. Source: 21 st MDTR Report 2013, NRR Figure 9.3.3(a): Cumulative distribution of iPTH, PD patients 2004-2013

55. Source: 21 st MDTR Report 2013, NRR Table 9.3.3(b): Distribution of iPTH, diabetic PD patients, 2004-2013 Year Number of Patients MeanSDMedianLQUQ Percent patients with iPTH: <150 pg/ml >150 & >300 pg/ml >300 & >500 pg/ml >500 pg/ml 2004 358127187.163.324.1145751545 2005 348161.4241.46722.5192.3701587 2006 434149.5198.488.932.5186.5681985 2007 544176.4204.611341.8237.85825116 2008 692211.3228.4141.256.3293.85124178 2009 750186.8184.913257.5255.55426137 2010 662197.1216.8131412955521168 2011 654188.9208.212844272.55424166 2012 679200.2214.813156282.55225157 2013 737173.6207.7112.544.2217592696

56. Source: 21 st MDTR Report 2013, NRR Figure 9.3.3(b): Cumulative distribution of iPTH, diabetic PD patients 2004-2013

57. Source: 21 st MDTR Report 2013, NRR Table 9.3.3(c): Distribution of iPTH, non diabetic PD patients 2004-2013 Year Number of Patients MeanSDMedianLQUQ Percent patients with iPTH: <150 pg/ml >150 & >300 pg/ml >300 & >500 pg/ml >500 pg/ml 2004 757258.6336.31385032553201214 2005 723288.3325.317248.8413.547191519 2006 831263.8295.916450386472116 2007 892292.333419157.5404.8442018 2008 916304.1331.7208.457.5422.541201820 2009 1074329.1336.7224.68046139201922 2010 1243295.8323.81875742545201520 2011 1386277.8307.7182.755.7387.545221617 2012 1585306.1314.8221.4704344021 19 2013 1863229.3265146.653.9312.151231610

58. Source: 21 st MDTR Report 2013, NRR Figure 9.3.3(c): Cumulative distribution of iPTH, non diabetic PD patients 2004-2013

59. Source: 21 st MDTR Report 2013, NRR Table 9.3.4(a): Variation in iPTH among HD centres 2004-2013 Year Number of centres Min 5 th Centile LQ Media n UQ 95 th Centile Max 2004 1373.6122973.8213392635 2005 1636.114.338.799.5220409.5626.4 2006 2237.716.841.593208.3377629.6 2007 24312.42046.3107.3231411.1643 2008 2898.522.457.9138.5243410712.5 2009 33410.42766.5156240.2391.8825.2 2010 3655.520.441.8105.8229.5384.8824 2011 4293.319.842.291.5219.5421.51249.3 2012 49211.132.474.8183284.1467.2768.3 2013 51910.322.544.898.5250.1423.9998.5

60. Source: 21 st MDTR Report 2013, NRR Figure 9.3.4(a): Variation in median iPTH among HD patients, HD centres 2013

61. Source: 21 st MDTR Report 2013, NRR Table 9.3.4(b): Variation in proportion of patients with iPTH 150-300pg/ml, HD centres 2004-2013 Year Number of centres Min 5 th Centile LQMedianUQ 95 th Centile Max 2004 13700510193850 2005 16300713203044 2006 22300714202947 2007 24300814203052 2008 28900916223143 2009 334001017243663 2010 36500714213345 2011 42900513203255 2012 492031017243353 2013 51900613223560

62. Source: 21 st MDTR Report 2013, NRR Figure 9.3.4(b): Variation in proportion of patients with iPTH 150-300pg/ml, HD centres, 2013

63. Source: 21 st MDTR Report 2013, NRR Table 9.3.5(a): Variation in median iPTH among PD patients 2004-2013 Year Number of centres Min 5 th Centile LQMedianUQ 95 th Centile Max 2004 1841 74.5137.3169.3303.8 2005 1825 85140.6259.5493.3 2006 2034.535.788.3165.6232.9313.3367 2007 2226.332107.3202.1241.8445.5513.9 2008 2234.554.6122.5186.2310.9352.3450 2009 234051129.1197.5315.64751171 2010 2429.432.7124.5216287.4517.3688.6 2011 2425.926.897.1187.6286.3365.5419 2012 2735.24684.8239324.5437452.5 2013 273742.169.2189.5270.4363.5457.5

64. Source: 21 st MDTR Report 2013, NRR Figure 9.3.5(a): Variation in median iPTH among PD patients, PD centres, 2013

65. Source: 21 st MDTR Report 2013, NRR Table 9.3.5(b): Proportion of patients with iPTH 150-300pg/ml Year Number of centres Min 5 th Centile LQMedianUQ 95 th Centile Max 2004 187714202432 2005 18001115.52433 2006 2055.51320.526.536.540 2007 22031520.5273239 2008 22071520.5263233 2009 2371113222628 2010 24041419.5263243 2011 24361322.5273338 2012 271717202731 2013 27031022323738

66. Source: 21 st MDTR Report 2013, NRR Figure 9.3.5(b): Variation in proportion of patients with iPTH 150-300pg/ml, PD centres 2013