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Control levels of transcription factor (TF) activity.

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Presentation on theme: "Control levels of transcription factor (TF) activity."— Presentation transcript:

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3 Control levels of transcription factor (TF) activity

4 How a TF activates the transcriptional machinery

5 Co-activators/repressors are required for TF function

6 Co-activators/repressors are shared among TFs

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8 Estrogen action

9 Gene regulation by the thyroid hormone receptor

10 Structure of a G protein-coupled receptor

11 Hormonal activation of adenylyl cyclase

12 Synthesis and degradation of cAMP

13 Regulation of protein kinase A

14 Cyclic AMP-inducible gene expression

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16 Regulation of protein phosphorylation by protein kinase A and protein phosphatase 1

17 Organization of receptor protein-tyrosine kinases

18 Dimerization and autophosphorylation of receptor protein-tyrosine kinases

19 Association of downstream signaling molecules with receptor protein-tyrosine kinases

20 Complex between an SH2 domain and a phosphotyrosine peptide

21 Signaling from cytokine receptors

22 Hydrolysis of PIP 2

23 Activation of phospholipase C by protein-tyrosine kinases

24 Ca 2+ mobilization by IP 3

25 Function of calmodulin

26 Activation of the ERK MAP kinases

27 Ras activation downstream of receptor protein-tyrosine kinases

28 Induction of immediate-early genes by ERK

29 Pathways of MAP kinase activation in mammalian cells

30 A scaffold protein for the JNK MAP kinase cascade

31 The JAK/STAT pathway

32 Signaling from TGF-  receptors

33 NF-  B signaling

34 Feedback inhibition of NF-  B

35 Crosstalk between G protein-coupled receptors and ERK signaling by  -arrestin


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