1. Review Classification of CT – CT “Proper” – Supporting CT – Fluid CT

2. Bone (osseous) CT

3. – Cells

4. Bone (osseous) CT – Cells Osteoprogenitor cell

5. Bone (osseous) CT – Cells Osteoprogenitor cell (stem cell)

6. Bone (osseous) CT – Cells Osteoprogenitor cell (stem cell) Osteoblasts

7. Bone (osseous) CT – Cells Osteoprogenitor cell (stem cell) Osteoblasts Osteocytes

8. Bone (osseous) CT – Cells Osteoprogenitor cell (stem cell) Osteoblasts Osteocytes (in lacunae)

9. Bone (osseous) CT – Cells Osteoprogenitor cell (stem cell) Osteoblasts Osteocytes (in lacunae) Osteoclasts

10. Bone (osseous) CT – Cells Osteoprogenitor cells (stem cells) Osteoblasts Osteocytes (in lacunae) Osteoclasts – Matrix

12. – Matrix: arranged as lamellae

14. Collagen fibers

15. – Matrix: arranged as lamellae Collagen fibers Calcium phosphate salts

16. – Matrix: arranged as lamellae Collagen fibers Calcium phosphate salts (as hydroxyapatite)

17. Arrangements of Bone Tissue

18. – Compact (cortical)

19. Arrangements of Bone Tissue – Compact (cortical) – Spongy (cancellous)

20. Compact Bone Tissue

21. – Location

22. Compact Bone Tissue – Location On bone surfaces

23. Compact Bone Tissue – Location On bone surfaces (matrix arranged as

24. Compact Bone Tissue – Location On bone surfaces (matrix arranged as circumferential lamellae)

25. Compact Bone Tissue – Location On bone surfaces (matrix arranged as circumferential lamellae) In shafts of long bones

26. Compact Bone Tissue – Location On bone surfaces (matrix arranged as circumferential lamellae) In shafts of long bones (matrix arranged as

27. Compact Bone Tissue – Location On bone surfaces (matrix arranged as circumferential lamellae) In shafts of long bones (matrix arranged as concentric

28. Compact Bone Tissue – Location On bone surfaces (matrix arranged as circumferential lamellae) In shafts of long bones (matrix arranged as concentric and interstitial lamellae)

29. – The osteon

30. – The osteon (Haversian system):

31. – The osteon (Haversian system): unit structure of thick compact bone  Haversian canal Lacuna  Canaliculi  *

32. Arrangements of Bone Tissue – Compact Bone Tissue

33. Arrangements of Bone Tissue – Compact Bone Tissue – Spongy (cancellous) bone tissue

34. Arrangements of Bone Tissue – Compact Bone Tissue – Spongy (cancellous) bone tissue Location: within bones

35. Arrangements of Bone Tissue – Compact Bone Tissue – Spongy (cancellous) bone tissue Location: within bones Consists of branching plates called trabeculae

36. Arrangements of Bone Tissue – Compact Bone Tissue – Spongy (cancellous) bone tissue Location: within bones Consists of branching plates called trabeculae

37. Arrangements of Bone Tissue – Compact Bone Tissue – Spongy (cancellous) bone tissue Location: within bones Consists of branching plates called trabeculae Bone marrow found between the trabecular spaces

38. Periosteum

39. – Fibrous layer

40. Periosteum – Fibrous layer – Cellular layer

41. Periosteum – Fibrous layer – Cellular layer Source of new oesteoblasts

42. Bone Tissue Remodelling

43. – Osteoblasts

44. Bone Tissue Remodelling – Osteoblasts – Osteoclasts *

46. Review Classification of CT – CT “Proper” – Supporting CT

47. Review Classification of CT – CT “Proper” – Supporting CT – Fluid CT

48. Review Classification of CT – CT “Proper” – Supporting CT – Fluid CT Blood

49. Review Classification of CT – CT “Proper” – Supporting CT – Fluid CT Blood Lymph

50. Blood

51. Blood =

52. Blood = Formed elements

53. Blood = Formed elements + plasma

54. – Formed elements

55. Blood = Formed elements + plasma – Formed elements (AKA “blood solids”)

56. Blood = Formed elements + plasma – Formed elements (AKA “blood solids”) RBC’S

57. Blood = Formed elements + plasma – Formed elements (AKA “blood solids”) RBC’S (erythrocytes)

58. Blood = Formed elements + plasma – Formed elements (AKA “blood solids”) RBC’S (erythrocytes) WBC’s

59. Blood = Formed elements + plasma – Formed elements (AKA “blood solids”) RBC’S (erythrocytes) WBC’s (leukocytes)

60. Blood = Formed elements + plasma – Formed elements (AKA “blood solids”) RBC’S (erythrocytes) WBC’s (leukocytes) platelets

61. Blood = Formed elements + plasma – Formed elements (AKA “blood solids”) RBC’S (erythrocytes) WBC’s (leukocytes) platelets (thrombocytes)

62. Red Blood Cells

63. – “bags” of hemoglobin *

64. White Blood Cells

65. – Granulocytes

66. White Blood Cells – Granulocytes Neutrophils

67. White Blood Cells – Granulocytes Neutrophils Eosinophils

68. White Blood Cells – Granulocytes Neutrophils Eosinophils Basophils

69. White Blood Cells – Granulocytes Neutrophils Eosinophils Basophils – Agranulocytes

70. White Blood Cells – Granulocytes Neutrophils Eosinophils Basophils – Agranulocytes Lymphocytes

71. White Blood Cells – Granulocytes Neutrophils Eosinophils Basophils – Agranulocytes Lymphocytes Monocytes

72. White Blood Cells – Granulocytes Neutrophils Eosinophils Basophils – Agranulocytes Lymphocytes Monocytes Basophil Neutrophil Eosinophil Lymphocyte Monocyte

73. Platelets (Thrombocytes)

74. REVIEW Blood = Formed elements + plasma – Formed elements (AKA “blood solids”) RBC’S (erythrocytes) WBC’s (leukocytes) platelets (thrombocytes)

75. Platelets (Thrombocytes) – Derived from megakaryocytes

76. Hemopoiesis – All formed elements develop from

77. Hemopoiesis – All formed elements develop from hemopoietic stem cells

78. Hemopoiesis – All formed elements develop from hemopoietic stem cells – Erythropoiesis

79. Hemopoiesis – All formed elements develop from hemopoietic stem cells – Erythropoiesis: regulated by erythropoiten (EPO)

80. Hemopoiesis – All formed elements develop from hemopoietic stem cells – Erythropoiesis: regulated by erythropoiten (EPO) – Leukopoiesis

81. Hemopoiesis – All formed elements develop from hemopoietic stem cells – Erythropoiesis: regulated by erythropoiten (EPO) – Leukopoiesis: regulated by numerous factors

82. Plasma

83. – Water

84. Plasma – Water – Electrolytes

85. Plasma – Water – Electrolytes – Organic nutrients

86. Plasma – Water – Electrolytes – Organic nutrients – Organic wastes

87. Plasma – Water – Electrolytes – Organic nutrients – Organic wastes – Plasma proteins

88. Albumin Globulins Clotting factors (e.g. fibrinogen) Regulatory hormones -----------------------