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Characterizing RNA Folding

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Presentation on theme: "Characterizing RNA Folding"— Presentation transcript:

1 Characterizing RNA Folding
Christine Wiersma Mentor: Dr. Wilma Olson DIMACS REU Rutgers University June 5, 2015

2 Ribonucleic Acid (RNA)
Composed of nucleotides String of nucleotides forms single stranded helix Helix bends and twists to create 3D structure Rana TM Chemical and structural features of RNA and DNA helices. Nature Reviews Molecular Cell Biology. Internet. Organic molecules: Carbs, proteins, lipids and nucleic acids What is Organic Chemistry? Science Prof Online. Internet

3 RNA Structure Structure is important to function Many functions
Protein synthesis Genetic material (in some viruses) Lu XJ, Bussemaker HJ, Olson WK. DSSR: an integrated software tool for dissecting the spatial structure of RNA. Preprint. Lu XJ, Bussemaker HJ, Olson WK. DSSR: an integrated software tool for dissecting the spatial structure of RNA. Preprint.

4 Previously Completed Research
DNA geometry and topology characterized Standard construction is ribbon model Clauvelin N, et al Characterization of the Geometry and Topology of DNA Pictured as a Discrete Collection of Atoms. J. Chem. Theory Comput Print.

5 Discrete DNA Model Compute writhing number, total twist, and linking number Clauvelin N, et al Characterization of the Geometry and Topology of DNA Pictured as a Discrete Collection of Atoms. J. Chem. Theory Comput Print.

6 RNA Ribbon Model DSSR software analyzes RNA tertiary structure
Able to create a ribbon structure from analysis Lu XJ, Bussemaker HJ, Olson WK. DSSR: an integrated software tool for dissecting the spatial structure of RNA. Preprint.

7 Goals and Methods Describe the geometry and topology of RNA
Modify previously used methods for DNA for use with RNA

8 References Brooker RJ Concepts of genetics. New York, NY: The McGraw-Hill Companies, Inc p. Clauvelin N, Olson WK, Tobias I Characterization of the geometry and topology of DNA pictured as a discrete collection of atoms. J. Chem. Theory Comput. 8: Lu XJ, Bussemaker HJ, Olson WK. DSSR: an integrated software tool for dissecting the spatial structure of RNA. Preprint.

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