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Molecular imaging using contrast-enhanced ultrasound: evaluation of angiogenesis and cell therapy by Howard Leong-Poi Cardiovasc Res Volume 84(2):190-200.

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Presentation on theme: "Molecular imaging using contrast-enhanced ultrasound: evaluation of angiogenesis and cell therapy by Howard Leong-Poi Cardiovasc Res Volume 84(2):190-200."— Presentation transcript:

1 Molecular imaging using contrast-enhanced ultrasound: evaluation of angiogenesis and cell therapy by Howard Leong-Poi Cardiovasc Res Volume 84(2):190-200 November 1, 2009 Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2009. For permissions please email: journals.permissions@oxfordjournals.org.

2 (A) Fluorescent microscopic images of the normal cremasteric microcirculation after intravenous injection of FITC–dextran to highlight the microvessels (left panel). Howard Leong-Poi Cardiovasc Res 2009;84:190-200 Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2009. For permissions please email: journals.permissions@oxfordjournals.org.

3 Background-subtracted colour-coded CEU images reflecting signal from microbubbles retained in Matrigel plugs 15 min after intravenous injection of microbubbles targeted to angiogenesis. Howard Leong-Poi Cardiovasc Res 2009;84:190-200 Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2009. For permissions please email: journals.permissions@oxfordjournals.org.

4 Background-subtracted colour-coded CEU images reflecting retention fraction of αVβ3-targeted microbubbles in ischaemic proximal hindlimb adductor muscles from control untreated and FGF-2-treated rats immediately after ligation (day 0) and at day 4 post-iliac artery ligation. Howard Leong-Poi Cardiovasc Res 2009;84:190-200 Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2009. For permissions please email: journals.permissions@oxfordjournals.org.

5 CEU molecular imaging data for microbubbles targeted to activated neutrophils (A), α5-integrin (B), and VCAM-1 (C) at various time points after femoral artery ligation in mice. Howard Leong-Poi Cardiovasc Res 2009;84:190-200 Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2009. For permissions please email: journals.permissions@oxfordjournals.org.

6 (A) Normalized microvascular blood flow in the ischaemic muscle for untreated (filled circles) and FGF-2-treated (open circles) animals. Howard Leong-Poi Cardiovasc Res 2009;84:190-200 Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2009. For permissions please email: journals.permissions@oxfordjournals.org.

7 Schematic diagram of potential strategies for CEU-targeted imaging of stem/progenitor cells, such as EPCs. One strategy involves manipulation/transfection of EPCs to express a specific marker protein on their surface. Howard Leong-Poi Cardiovasc Res 2009;84:190-200 Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2009. For permissions please email: journals.permissions@oxfordjournals.org.

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