1. CTIIP Coordination Co-clinical/animal models July 29, 2015

2. Contract Period of Performance Digital Pathology and Integrative Query –July 24, 2014 – January 23, 2016 DICOM WG-30 –June 26, 2014 – June 25, 2015 Pilot Challenges –December 18, 2014 – June 17, 2016 Co-clinical and animal model data –April 15, 2015 – April 14, 2016

3. Dependencies / Linking of Projects Creation of Controlled Vocabulary and Codes for Integrative Query System Issues: A. NCIT incomplete in anatomy and pathology nomenclature for mouse and human. Examples: 1. No codes for IHC Staining Methods for Breast Cancer 2. No codes for mouse transplantation 3. Limited, outdated codes for mouse mammary tumors 3. No codes for specific GEM models (use MGI codes?) 4. Confusion in anatomic designations of breast vs mammary B. DICOM Identifiers 1. Using UCD Accession Number-Animal number? 2. Human? Solutions: Working with EVS team to resolve issues. 1. New codes for IHC Methods in place 2, List of mouse transplantation terms provided EVS 3. NEXT: Codes for Mouse Mammary Tumors. Discussion with Drs. Clunie and Prior. Pending Resolution Issue: How granular should we get? 3 UC Davis team to provide input on markup and annotations for animal images UC Davis team = user acceptance testing during development

4. NCIT IHC STAINING METHODS

5. Dependencies / Linking of Projects Creation of Controlled Vocabulary and Codes for Integrative Query System Issues: A. NCIT incomplete in anatomy and pathology nomenclature for mouse and human. Examples: 1. No codes for IHC Staining Methods for Breast Cancer 2. No codes for mouse transplantation 3. Limited, outdated codes for mouse mammary tumors 3. No codes for specific GEM models (use MGI codes?) 4. Confusion in anatomic designations of breast vs mammary B. DICOM Identifiers 1. Using UCD Accession Number-Animal number? 2. Human? 3 Solutions: Working with EVS team to resolve issues. 1. New codes for IHC Methods in place 2, List of mouse transplantation terms provided EVS 3. NEXT: Codes for Mouse Mammary Tumors. Discussion with Drs. Clunie and Prior. Pending Resolution Issue: How granular should we get? 5 UC Davis team to provide input on markup and annotations for animal images UC Davis team = user acceptance testing during development

6. Timeline – Co-clinical/animal model Submit Whole Slide Images and DemographicsSubmit Whole Slide Images and Demographics –May – October 2015 –Prototype Three human and mouse cases with WSI and NCIT codes submitted To Dr. Sharma on 5-22-15 As per Dr. Sharma’s request emphasis in use-cases on IHC4 biomarkers Full collection ready but PENDIING Dr. Sharma’s approval of Prototype collection –User Evaluation of caMicroscope and Integrative Query System: PENDING ACCESS –Issue: Controlled Vocabulary and codes. Vocabulary for 24 new IHC Methods: Submitted 7-7-15 and posted Vocabulary for mouse transplantation: Submitted 7-17-15 Vocabulary for mouse mammary tumor classification. PENDING PathAIM mark up and annotations –June – October 2015 Pending CMGI ImagesPrepare CMGI Images –May – July 2015 –Submitted to first three sets to Wash U: 7-7-15 –Pending instructions and headers from Imaging Groups Mark up In-Vivo Images –July – August 2015 –Pending instructions CMGI imagesSubmit CMGI images –July – November 2015 –Pending Instructions human BrCa casesIdentify and prepare human BrCa cases –July – September 2015 –Identification completed. Preparation and Submission pending instructions human BrCA ImagesSubmit human BrCA Images –November 2015 – April 2016 6

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