1. CTIIP Coordination Co-clinical/animal models June 24, 2015

2. Contract Period of Performance Digital Pathology and Integrative Query –July 24, 2014 – January 23, 2016 DICOM WG-30 –June 26, 2014 – June 25, 2015 Pilot Challenges –December 18, 2014 – June 17, 2016 Co-clinical and animal model data –April 15, 2015 – April 14, 2016

3. Timeline – Co-clinical/animal model Submit Whole Slide Images and DemographicsSubmit Whole Slide Images and Demographics –May – October 2015 –Prototype WSI human and mouse submitted To Dr. Sharma. As per Dr. Sharma’s request emphasis in use-cases on IHC4 biomarkers Full collection ready but pending Dr. Sharma’s approval of Prototype collection –Issue: Controlled Vocabulary and codes. PathAIM mark up and annotations –June – October 2015 Pending CMGI ImagesPrepare CMGI Images –May – July 2015 –Pending instructions and headers from Imaging Group Mark up In-Vivo Images –July – August 2015 –Pending instructions CMGI imagesSubmit CMGI images –July – November 2015 –Pending Instructions human BrCa casesIdentify and prepare human BrCa cases –July – September 2015 –Identification completed. Preparation and Submission pending instructions human BrCA ImagesSubmit human BrCA Images –November 2015 – April 2016 3

4. Dependencies / Linking of Projects Creation of Controlled Vocabulary and Codes for Integrative Query System Issue: NCIT incomplete in anatomy and pathology nomenclature for mouse and human. Examples: 1. No codes for IHC of ER, PR, or Ki67 2. Limited, outdated codes for mouse mammary tumors 3. No codes for specific GEM models (use MGI codes?) 4. Confusion in anatomic designations of breast vs mammary Solution: Working with EVS team to resolve issues. New codes for ER, PR, and Ki67 Issue: How granular should we get? 4 UC Davis team to provide input on markup and annotations for animal images UC Davis team = user acceptance testing during development