1. PowerPoint ® Lecture Slides prepared by Janice Meeking, Mount Royal College C H A P T E R Copyright © 2010 Pearson Education, Inc. 12 The Central Nervous System: Part A

2. Copyright © 2010 Pearson Education, Inc. Central Nervous System (CNS) CNS consists of the brain and spinal cord Cephalization Evolutionary development of the rostral (anterior) portion of the CNS Increased number of neurons in the head Highest level is reached in the human brain

3. Copyright © 2010 Pearson Education, Inc. Embryonic Development Neural plate forms from ectoderm Neural plate invaginates to form a neural groove and neural folds

4. Copyright © 2010 Pearson Education, Inc. Figure 12.1, step 1 The neural plate forms from surface ectoderm. 1 Head Tail Surface ectoderm Neural plate

5. Copyright © 2010 Pearson Education, Inc. Figure 12.1, step 2 The neural plate invaginates, forming the neural groove, flanked by neural folds. 2 Neural folds Neural groove

6. Copyright © 2010 Pearson Education, Inc. Embryonic Development Neural groove fuses dorsally to form the neural tube Neural tube gives rise to the brain and spinal cord

7. Copyright © 2010 Pearson Education, Inc. Figure 12.1, step 3 Neural fold cells migrate to form the neural crest, which will form much of the PNS and many other structures. 3 Neural crest

8. Copyright © 2010 Pearson Education, Inc. Figure 12.1, step 4 The neural groove becomes the neural tube, which will form CNS structures. 4 Surface ectoderm Head Tail Neural tube

9. Copyright © 2010 Pearson Education, Inc. Embryonic Development Anterior end of the neural tube gives rise to three primary brain vesicles Prosencephalon—forebrain Mesencephalon—midbrain Rhombencephalon—hindbrain

10. Copyright © 2010 Pearson Education, Inc. (a) Neural tube (b) Primary brain vesicles Anterior (rostral) Posterior (caudal) Rhombencephalon (hindbrain) Mesencephalon (midbrain) Prosencephalon (forebrain) Figure 12.2a-b

11. Copyright © 2010 Pearson Education, Inc. Embryonic Development Primary vesicles give rise to five secondary brain vesicles Telencephalon and diencephalon arise from the forebrain Mesencephalon remains undivided Metencephalon and myelencephalon arise from the hindbrain

12. Copyright © 2010 Pearson Education, Inc. Embryonic Development Telencephalon  cerebrum (two hemispheres with cortex, white matter, and basal nuclei) Diencephalon  thalamus, hypothalamus, epithalamus, and retina

13. Copyright © 2010 Pearson Education, Inc. Embryonic Development Mesencephalon  brain stem (midbrain) Metencephalon  brain stem (pons) and cerebellum Myelencephalon  brain stem (medulla oblongata) Central canal of the neural tube enlarges to form fluid-filled ventricles

14. Copyright © 2010 Pearson Education, Inc. (d) Adult brain structures (c) Secondary brain vesicles Spinal cord Cerebellum Brain stem: medulla oblongata Brain stem: pons Brain stem: midbrain Diencephalon (thalamus, hypothalamus, epithalamus), retina Cerebrum: cerebral hemispheres (cortex, white matter, basal nuclei) Myelencephalon Metencephalon Mesencephalon Diencephalon Telencephalon Central canal Fourth ventricle Cerebral aqueduct Third ventricle Lateral ventricles (e) Adult neural canal regions Figure 12.2c-e

15. Copyright © 2010 Pearson Education, Inc. Effect of Space Restriction on Brain Development Midbrain flexure and cervical flexure cause forebrain to move toward the brain stem Cerebral hemispheres grow posteriorly and laterally Cerebral hemisphere surfaces crease and fold into convolutions

16. Copyright © 2010 Pearson Education, Inc. Figure 12.3a Metencephalon Anterior (rostral)Posterior (caudal) Mesencephalon Diencephalon Midbrain Cervical Spinal cord Flexures Telencephalon Myelencephalon (a) Week 5

17. Copyright © 2010 Pearson Education, Inc. Figure 12.3b Midbrain Cerebellum Pons Medulla oblongata Spinal cord Cerebral hemisphere Outline of diencephalon (b) Week 13

18. Copyright © 2010 Pearson Education, Inc. Figure 12.3c Cerebellum Pons Medulla oblongata Spinal cord Cerebral hemisphere (c) Week 26

19. Copyright © 2010 Pearson Education, Inc. Regions and Organization of the CNS Adult brain regions 1.Cerebral hemispheres 2.Diencephalon 3.Brain stem (midbrain, pons, and medulla) 4.Cerebellum

20. Copyright © 2010 Pearson Education, Inc. Figure 12.3d Cerebellum Diencephalon Cerebral hemisphere (d) Birth Brain stem Midbrain Pons Medulla oblongata

21. Copyright © 2010 Pearson Education, Inc. Regions and Organization of the CNS Spinal cord Central cavity surrounded by a gray matter core External white matter composed of myelinated fiber tracts

22. Copyright © 2010 Pearson Education, Inc. Regions and Organization of the CNS Brain Similar pattern with additional areas of gray matter Nuclei in cerebellum and cerebrum Cortex of cerebellum and cerebrum

23. Copyright © 2010 Pearson Education, Inc. Figure 12.4 Cerebrum Cerebellum Migratory pattern of neurons Cortex of gray matter Inner gray matter Gray matter Outer white matter Central cavity Inner gray matter Gray matter Outer white matter Central cavity Inner gray matter Outer white matter Region of cerebellum Brain stem Spinal cord

24. Copyright © 2010 Pearson Education, Inc. Ventricles of the Brain Connected to one another and to the central canal of the spinal cord Lined by ependymal cells

25. Copyright © 2010 Pearson Education, Inc. Ventricles of the Brain Contain cerebrospinal fluid Two C-shaped lateral ventricles in the cerebral hemispheres Third ventricle in the diencephalon Fourth ventricle in the hindbrain, dorsal to the pons, develops from the lumen of the neural tube

26. Copyright © 2010 Pearson Education, Inc. Figure 12.5 Anterior horn Interventricular foramen Inferior horn Lateral aperture (b) Left lateral view Lateral ventricle Septum pellucidum Third ventricle Cerebral aqueduct (a) Anterior view Fourth ventricle Central canal Inferior horn Posterior horn Median aperture Lateral aperture

27. Copyright © 2010 Pearson Education, Inc. Cerebral Hemispheres Surface markings Ridges (gyri), shallow grooves (sulci), and deep grooves (fissures) Five lobes Frontal Parietal Temporal Occipital Insula

28. Copyright © 2010 Pearson Education, Inc. Cerebral Hemispheres Surface markings Central sulcus Separates the precentral gyrus of the frontal lobe and the postcentral gyrus of the parietal lobe Longitudinal fissure Separates the two hemispheres Transverse cerebral fissure Separates the cerebrum and the cerebellum PLAY Animation: Rotatable brain

29. Copyright © 2010 Pearson Education, Inc. Figure 12.6a Postcentral gyrus Central sulcus Precentral gyrus Frontal lobe (a) Parietal lobe Parieto-occipital sulcus (on medial surface of hemisphere) Lateral sulcus Transverse cerebral fissure Occipital lobe Temporal lobe Cerebellum Pons Medulla oblongata Spinal cord Cortex (gray matter) Fissure (a deep sulcus) Gyrus Sulcus White matter

30. Copyright © 2010 Pearson Education, Inc. Figure 12.6b Central sulcus (b) Frontal lobe Temporal lobe (pulled down) Gyri of insula

31. Copyright © 2010 Pearson Education, Inc. Figure 12.6c Parietal lobe Frontal lobe Right cerebral hemisphere Occipital lobe Left cerebral hemisphere Cerebral veins and arteries covered by arachnoid mater Longitudinal fissure Posterior (c) Anterior

32. Copyright © 2010 Pearson Education, Inc. Figure 12.6d Left cerebral hemisphere Transverse cerebral fissure Cerebellum Brain stem (d)

33. Copyright © 2010 Pearson Education, Inc. Cerebral Cortex Thin (2–4 mm) superficial layer of gray matter 40% of the mass of the brain Site of conscious mind: awareness, sensory perception, voluntary motor initiation, communication, memory storage, understanding Each hemisphere connects to contralateral side of the body There is lateralization of cortical function in the hemispheres

34. Copyright © 2010 Pearson Education, Inc. Functional Areas of the Cerebral Cortex The three types of functional areas are: Motor areas—control voluntary movement Sensory areas—conscious awareness of sensation Association areas—integrate diverse information Conscious behavior involves the entire cortex

35. Copyright © 2010 Pearson Education, Inc. Motor Areas Primary (somatic) motor cortex Premotor cortex Broca’s area Frontal eye field

36. Copyright © 2010 Pearson Education, Inc. Figure 12.8a Gustatory cortex (in insula) Primary motor cortex Premotor cortex Frontal eye field Working memory for spatial tasks Executive area for task management Working memory for object-recall tasks Broca’s area (outlined by dashes) Solving complex, multitask problems (a) Lateral view, left cerebral hemisphere Motor areas Prefrontal cortex Sensory areas and related association areas Central sulcus Primary somatosensory cortex Somatosensory association cortex Somatic sensation Taste Wernicke’s area (outlined by dashes) Primary visual cortex Visual association area Vision Auditory association area Primary auditory cortex Hearing Primary motor cortex Motor association cortex Primary sensory cortex Sensory association cortex Multimodal association cortex

37. Copyright © 2010 Pearson Education, Inc. Primary Motor Cortex Large pyramidal cells of the precentral gyri Long axons  pyramidal (corticospinal) tracts Allows conscious control of precise, skilled, voluntary movements Motor homunculi: upside-down caricatures representing the motor innervation of body regions

38. Copyright © 2010 Pearson Education, Inc. Figure 12.9 Toes Swallowing Tongue Jaw Primary motor cortex (precentral gyrus) Motor Motor map in precentral gyrus Posterior Anterior

39. Copyright © 2010 Pearson Education, Inc. Premotor Cortex Anterior to the precentral gyrus Controls learned, repetitious, or patterned motor skills Coordinates simultaneous or sequential actions Involved in the planning of movements that depend on sensory feedback

40. Copyright © 2010 Pearson Education, Inc. Broca’s Area Anterior to the inferior region of the premotor area Present in one hemisphere (usually the left) A motor speech area that directs muscles of the tongue Is active as one prepares to speak

41. Copyright © 2010 Pearson Education, Inc. Frontal Eye Field Anterior to the premotor cortex and superior to Broca’s area Controls voluntary eye movements

42. Copyright © 2010 Pearson Education, Inc. Sensory Areas Primary somatosensory cortex Somatosensory association cortex Visual areas Auditory areas Olfactory cortex Gustatory cortex Visceral sensory area Vestibular cortex

43. Copyright © 2010 Pearson Education, Inc. Figure 12.8a Gustatory cortex (in insula) Primary motor cortex Premotor cortex Frontal eye field Working memory for spatial tasks Executive area for task management Working memory for object-recall tasks Broca’s area (outlined by dashes) Solving complex, multitask problems (a) Lateral view, left cerebral hemisphere Motor areas Prefrontal cortex Sensory areas and related association areas Central sulcus Primary somatosensory cortex Somatosensory association cortex Somatic sensation Taste Wernicke’s area (outlined by dashes) Primary visual cortex Visual association area Vision Auditory association area Primary auditory cortex Hearing Primary motor cortex Motor association cortex Primary sensory cortex Sensory association cortex Multimodal association cortex

44. Copyright © 2010 Pearson Education, Inc. Primary Somatosensory Cortex In the postcentral gyri Receives sensory information from the skin, skeletal muscles, and joints Capable of spatial discrimination: identification of body region being stimulated

45. Copyright © 2010 Pearson Education, Inc. Figure 12.9 Genitals Intra- abdominal Primary somato- sensory cortex (postcentral gyrus) Sensory Sensory map in postcentral gyrus Posterior Anterior

46. Copyright © 2010 Pearson Education, Inc. Somatosensory Association Cortex Posterior to the primary somatosensory cortex Integrates sensory input from primary somatosensory cortex Determines size, texture, and relationship of parts of objects being felt

47. Copyright © 2010 Pearson Education, Inc. Visual Areas Primary visual (striate) cortex Extreme posterior tip of the occipital lobe Most of it is buried in the calcarine sulcus Receives visual information from the retinas

48. Copyright © 2010 Pearson Education, Inc. Visual Areas Visual association area Surrounds the primary visual cortex Uses past visual experiences to interpret visual stimuli (e.g., color, form, and movement) Complex processing involves entire posterior half of the hemispheres

49. Copyright © 2010 Pearson Education, Inc. Auditory Areas Primary auditory cortex Superior margin of the temporal lobes Interprets information from inner ear as pitch, loudness, and location Auditory association area Located posterior to the primary auditory cortex Stores memories of sounds and permits perception of sounds

50. Copyright © 2010 Pearson Education, Inc. OIfactory Cortex Medial aspect of temporal lobes (in piriform lobes) Part of the primitive rhinencephalon, along with the olfactory bulbs and tracts (Remainder of the rhinencephalon in humans is part of the limbic system) Region of conscious awareness of odors

51. Copyright © 2010 Pearson Education, Inc. Gustatory Cortex In the insula Involved in the perception of taste

52. Copyright © 2010 Pearson Education, Inc. Visceral Sensory Area Posterior to gustatory cortex Conscious perception of visceral sensations, e.g., upset stomach or full bladder

53. Copyright © 2010 Pearson Education, Inc. Vestibular Cortex Posterior part of the insula and adjacent parietal cortex Responsible for conscious awareness of balance (position of the head in space)

54. Copyright © 2010 Pearson Education, Inc. Figure 12.8a Gustatory cortex (in insula) Primary motor cortex Premotor cortex Frontal eye field Working memory for spatial tasks Executive area for task management Working memory for object-recall tasks Broca’s area (outlined by dashes) Solving complex, multitask problems (a) Lateral view, left cerebral hemisphere Motor areas Prefrontal cortex Sensory areas and related association areas Central sulcus Primary somatosensory cortex Somatosensory association cortex Somatic sensation Taste Wernicke’s area (outlined by dashes) Primary visual cortex Visual association area Vision Auditory association area Primary auditory cortex Hearing Primary motor cortex Motor association cortex Primary sensory cortex Sensory association cortex Multimodal association cortex

55. Copyright © 2010 Pearson Education, Inc. Figure 12.8b Frontal eye field Prefrontal cortex Processes emotions related to personal and social interactions (b) Parasagittal view, right hemisphere Olfactory bulb Orbitofrontal cortex Olfactory tract Fornix Temporal lobe Corpus callosum Premotor cortex Primary motor cortex Cingulate gyrus Central sulcus Primary somatosensory cortex Parietal lobe Parieto-occipital sulcus Somatosensory association cortex Occipital lobe Visual association area Calcarine sulcus Parahippocampal gyrus Uncus Primary olfactory cortex Primary visual cortex Primary motor cortex Motor association cortex Primary sensory cortex Sensory association cortex Multimodal association cortex

56. Copyright © 2010 Pearson Education, Inc. Multimodal Association Areas Receive inputs from multiple sensory areas Send outputs to multiple areas, including the premotor cortex Allow us to give meaning to information received, store it as memory, compare it to previous experience, and decide on action to take

57. Copyright © 2010 Pearson Education, Inc. Multimodal Association Areas Three parts Anterior association area (prefrontal cortex) Posterior association area Limbic association area

58. Copyright © 2010 Pearson Education, Inc. Anterior Association Area (Prefrontal Cortex) Most complicated cortical region Involved with intellect, cognition, recall, and personality Contains working memory needed for judgment, reasoning, persistence, and conscience Development depends on feedback from social environment

59. Copyright © 2010 Pearson Education, Inc. Posterior Association Area Large region in temporal, parietal, and occipital lobes Plays a role in recognizing patterns and faces and localizing us in space Involved in understanding written and spoken language (Wernicke’s area)

60. Copyright © 2010 Pearson Education, Inc. Limbic Association Area Part of the limbic system Provides emotional impact that helps establish memories