1. 27-1 Chapter 27 Lecture Outline See PowerPoint Image Slides for all figures and tables pre-inserted into PowerPoint without notes. Copyright (c) The McGraw-Hill Companies, Inc. Permission required for reproduction or display.

2. 27-2 Male Reproductive System Sexual reproduction and development Male reproductive anatomy Puberty and climacteric Sperm and semen Male sexual response

3. 27-3 Essence of Sex Reproduction –one property of a living thing –great variety of methods Sexual reproduction –each offspring has 2 parents and receives genetic material from both –provides genetic diversity –foundation for survival and evolution of species

4. 27-4 Two Sexes Male and female gametes (sex cells) combine their genes to form a fertilized egg (zygote) –one gamete has motility (sperm) parent producing sperm considered male has Y chromosome –other gamete (egg or ovum) contains nutrients for developing zygote parent producing eggs considered female in mammals female also provides shelter for developing fetus (uterus and placenta)

5. 27-5 Overview of Reproductive System Primary sex organs –produce gametes (testes or ovaries) Secondary sex organs –male - ducts, glands, penis deliver sperm cells –female - uterine tubes, uterus and vagina receive sperm and nourish developing fetus Secondary sex characteristics –develop at puberty to attract a mate pubic, axillary and facial hair, scent glands, body morphology and low-pitched voice in males

6. 27-6 Our cells contain 23 pairs of chromosomes –22 pairs of autosomes –1 pair of sex chromosomes (XY males: XX females) males produce 50% Y carrying sperm and 50% X carrying all eggs carry the X chromosome Sex of child determined by type of sperm that fertilizes mother’s egg Role of Sex Chromosomes

7. 27-7 Hormones and Sex Differentiation Gonads begin to develop at 6 weeks 2 sets of ducts –mesonephric ducts develop into male reproductive system or –paramesonephric ducts (müllerian ducts) develop into female reproductive tract SRY gene (Sex-determining Region of Y gene) –in males, codes for a protein that causes development of testes  secrete testosterone secrete müllerian-inhibiting factor  degenerates paramesonephric ducts Female development occurs in absence of hormones

8. 27-8 Embryonic Development External genitals of both sexes begin as a –genital tubercle becomes glans of penis or clitoris –pair of urogenital folds enclose urethra of male or form labia minora –a pair of labioscrotal folds scrotum or labia majora

9. 27-9 Embryonic Development

10. 27-10 Androgen-Insensitivity Syndrome Genetically male (XY) Testosterone secreted –target cells lack receptors for hormone No masculizing effects occur

11. 27-11 Development of External Genitalia

12. 27-12 Development of External Genitalia All 8 week old fetuses have same 3 structures –by end of week 9, begin to show sexual differentiation –distinctly male or female by end of week 12

13. 27-13 Testes Oval organ, 4 cm long x 2.5 cm in diameter –covered anteriorly by tunica vaginalis Tunica albuginea –white fibrous capsule on testes Septa divide testes into compartments containing seminiferous tubules –each tubule lined with a thick germinal epithelium for sperm –interstitial cells between tubules - testosterone Sustentacular cells –promote sperm cell development

14. 27-14 Blood-testis barrier Formed by tight junctions between sustentacular cells -- separating sperm from immune system

15. 27-15 Reproductive system remains dormant for years after birth –surge of pituitary gonadotropins begins development 10-12 in most boys; 8-10 in most girls Puberty –period from onset of gonadotropin secretion until first menstrual period or first ejaculation of viable sperm Adolescence –ends when person attains full adult height

16. 27-16 Brain-Testicular Axis Hypothalamus produces GnRH Stimulates anterior pituitary (gonadotrope cells) to secrete –LH stimulates interstitial cells to produce testosterone –FSH stimulates sustentacular cells to secrete androgen- binding protein that interacts with testosterone to stimulate spermatogenesis

17. 27-17 Other Effects of Testosterone Enlargement of secondary sexual organs –penis, testes, scrotum, ducts, glands and muscle mass enlarge –hair, scent and sebaceous glands develop –stimulates erythropoiesis and libido During adulthood, testosterone sustains libido, spermatogenesis and reproductive tract

18. 27-18 Hormones and Brain-Testicular Axis

19. 27-19 Aging and Sexual Function Decline in testosterone secretion –peak secretion at 7 mg/day at age 20 –declines to 1/5 of that by age 80 Rise in FSH and LH secretion after age 50 produces male climacteric (menopause) –mood changes, hot flashes and “illusions of suffocation” Erectile dysfunction –20% of men in 60s; 50% of those in 80s

20. 27-20 Mitosis and Meiosis Mitosis produces two genetically identical daughter cells (for tissue repair, embryonic growth) Meiosis produces gametes –for sexual reproduction keeps chromosome number constant from generation to generation after fertilization –2 cell divisions (only one replication of DNA) meiosis I separates homologous chromosome pairs into 2 haploid cells meiosis II separates duplicated sister chromatids into 4 haploid cells

21. 27-21 Meiosis

22. 27-22 Spermatogonia produce 2 kinds of daughter cells –type A remain outside blood-testis barrier and produce more daughter cells until death –type B differentiate into primary spermatocytes cells must pass through BTB to move inward toward lumen - new tight junctions form behind these cells meiosis I  2 secondary spermatocytes meiosis II  4 spermatids Spermatogenesis

23. 27-23 Spermatogenesis Blood-testis barrier is formed by tight junctions between and basement membrane under sustentacular cells.

24. 27-24 Spermiogenesis Changes that transform spermatids into spermatozoa –discarding excess cytoplasm and growing tails

25. 27-25 Spermatozoon Head is pear-shaped front end –4 to 5 microns long structure containing the nucleus, acrosome and basal body of the tail flagella nucleus contains haploid set of chromosomes acrosome contains enzymes that penetrate the egg basal body Tail is divided into 3 regions –midpiece contains mitochondria around axoneme of the flagella (produce ATP for flagellar movement) –principal piece is axoneme surrounded by fibers –endpiece is very narrow tip of flagella

26. 27-26 Spermatozoon