1. National Cancer Institute U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health In-home Coal Use and Lung Cancer Risk H. Dean Hosgood, III, PhD, MPH Qing Lan, PhD, MD Occupational & Environmental Epidemiology Branch Division of Cancer Epidemiology and Genetics National Cancer Institute

2. Search Strategy – Keywords Air pollution keywords and Air pollution keywords and – ("IAP" OR "Indoor air" OR "pollution" OR "pollutant" OR "fuel" OR "fuels" OR "coal" OR “coals” OR "charcoal" OR “charcoals” OR “cake” OR “cakes” OR “briquette” OR “briquettes” OR “solid fuel” OR “solid fuels” OR “biomass” OR “anthracite” OR “bituminous” OR “fossil fuel” OR “fossil fuels” OR “lignite” OR “subbituminous” OR "stove" OR "stoves" OR "chula" OR "chulla" OR "oven" OR "ovens" OR "smoke" OR "smoky" OR heat* OR cook* OR light* OR burn*) AND Lung cancer keywords Lung cancer keywords – ("lung" OR "bronchus" OR "bronchial" OR "bronchogenic" OR "pulmonary" OR "lower respiratory tract" OR "trachea") AND – ("cancer" OR "cancers" OR "carcinoma" OR "carcinomata" OR "neoplasm" OR "neoplasms" OR "tumor" OR "tumors" OR "tumours" OR "tumour" OR "adenocarcinoma" OR "adenocarcinomata" OR "*small-cell") Hosgood et al.

3. Search Strategy – Databases PubMed and Science Citation Index PubMed and Science Citation Index – Studies in humans published January1966 - June 2009 China National Knowledge Infrastructure and Science Periodical Database of China China National Knowledge Infrastructure and Science Periodical Database of China – Articles published through June 2009 with in:  (A)Mathematics/ Physics/ Mechanics/ Astronomy  (B) Chemistry/ Metallurgy/ Environment/ Mine Industry  (C) Architecture/ Energy/ Traffic/ Electromechanics  (D) Agriculture  (E) Medicine & Public Health  (F) Literature/ History/ Philosophy  (G) Politics/ Military Affairs/ Law  (H) Education & Social Sciences  (I) Electronic Technology & Information Science  (J) Economics & Managementusing models Hosgood et al.

4. Search Strategy – Additional Searches Reviewed bibliography of all published articles reviewed in full Reviewed bibliography of all published articles reviewed in full Reviewed bibliography of the two previously published meta-analyses in Chinese Reviewed bibliography of the two previously published meta-analyses in Chinese Reviewed bibliography of previous IARC monograph Reviewed bibliography of previous IARC monograph Hosgood et al.

5. Inclusion Criteria Case-control study Case-control study Provide OR and 95%CI or enough information to calculate OR and 95%CI Provide OR and 95%CI or enough information to calculate OR and 95%CI In-home exposure only, not occupational or urban exposures In-home exposure only, not occupational or urban exposures Differentiate coal association from other biomass fuels Differentiate coal association from other biomass fuels Population not part of previously published study Population not part of previously published study Hosgood et al.

6. Studies Identified EnglishChinese Initial keyword search82892077 Remained after title review / Abstracts reviewed542100 Papers reviewed in full5768 Papers included in analysis2113

7. Statistical Methods Used unadjusted OR and 95%CI from each study Used unadjusted OR and 95%CI from each study – Results were similar when using adjusted ORs and 95%Cs from studies that reported them Random-effects model Random-effects model Heterogeneity among studies determined by a χ2- based Q-statistic Heterogeneity among studies determined by a χ2- based Q-statistic Funnel plots Funnel plots Begg’s test Begg’s test Hosgood et al.

9. 2.18 (1.76-2.70)

10. Hosgood et al.