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Angiopoietin-1 prevents hypertension and target organ damage through its interaction with endothelial Tie2 receptor by Jung-Sun Lee, Sun-Hwa Song, Jeong-Min.

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Presentation on theme: "Angiopoietin-1 prevents hypertension and target organ damage through its interaction with endothelial Tie2 receptor by Jung-Sun Lee, Sun-Hwa Song, Jeong-Min."— Presentation transcript:

1 Angiopoietin-1 prevents hypertension and target organ damage through its interaction with endothelial Tie2 receptor by Jung-Sun Lee, Sun-Hwa Song, Jeong-Min Kim, In-Soon Shin, Koung Li Kim, Yeon-Lim Suh, Hak-Zoo Kim, Gou Young Koh, Jonghoe Byun, Eun-Seok Jeon, Wonhee Suh, and Duk-Kyung Kim Cardiovasc Res Volume 78(3):572-580 June 1, 2008 Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2008. For permissions please email: journals.permissions@oxfordjournals.org

2 COMP-Ang-1 gene transfer prevents the blood pressure (BP) elevation in spontaneously hypertensive rats (SHRs). Jung-Sun Lee et al. Cardiovasc Res 2008;78:572-580 Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2008. For permissions please email: journals.permissions@oxfordjournals.org

3 COMP-Ang-1 gene transfer reduces myocardial damage in SHRs. (A) Representative images of H&E-stained heart. Jung-Sun Lee et al. Cardiovasc Res 2008;78:572-580 Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2008. For permissions please email: journals.permissions@oxfordjournals.org

4 COMP-Ang-1 gene transfer reduces renal damage in SHRs. (A) Representative images of H&E- stained kidney. Jung-Sun Lee et al. Cardiovasc Res 2008;78:572-580 Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2008. For permissions please email: journals.permissions@oxfordjournals.org

5 COMP-Ang-1 gene transfer attenuates the microvascular rarefaction and tissue ischaemia in the heart and kidney of SHRs. The microvasculature of the heart (A) [arrowheads in (A) indicate the absence of capillaries], (B) and kidney (C) was visualized and quantified by immunohistochemical staining with CD31 IgG on frozen sections or RECA IgG on paraffin sections, respectively. Jung-Sun Lee et al. Cardiovasc Res 2008;78:572-580 Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2008. For permissions please email: journals.permissions@oxfordjournals.org

6 COMP-Ang-1 protein induces beneficial effects in SHRs via Tie2 receptors on endothelium. Jung-Sun Lee et al. Cardiovasc Res 2008;78:572-580 Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2008. For permissions please email: journals.permissions@oxfordjournals.org

7 COMP-Ang-1 enhances nitric oxide production by activating endothelial nitric oxide synthase (eNOS). Jung-Sun Lee et al. Cardiovasc Res 2008;78:572-580 Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2008. For permissions please email: journals.permissions@oxfordjournals.org

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