2. 4-th INTERNATIONAL CONFERENCE ON TRANSLATIONAL MEDICINE OCTOBER 26-28, 2015 BALTIMORE, MARYLAND, USA Translational medicine – our approach. ALEXANDER V MELERZANOV MD PHD DEAN OF BIOLOGICAL AND MEDICAL PHYSICS DEPARTMENT MOSCOW INSTITUTE OF PHYSICS AND TECHNOLOGY (STATE UNIVERSITY)

3. MIPT HISTORY  For the time of MIPT’s existence 8 Nobel prize winners were its professors and founders  2 Nobel prize laureates for graphene in 2010 are MIPT graduates

4. MIPT ADVISORY BOARD

5. MIPT –LEADING RUSSIAN TECH UNIVERSITY EDUCATIONAL MISSION:  Cross-disciplinary training of highly qualified specialists based on mandatory participation of all students in research practice ; STRATEGICAL GOAL:  Elaboration and transfer of new technologies into industry FOR REFERENCE:  1st among high schools by average exam score of entrants;  1st place among RUS technical universities ;  2-3d place in the RUS universities rating;  ~ 3000 undergraduates  ~ 2500 graduates FOR less then 65-YEARS HISTORY:  10 Nobel prize laureates  ~150 Members of Russian Academy of Sciences;  ~ 6000 Doctors of Science;

6. NEW DEFINITIONS FOR MEDICINE TRANSLATIONAL MEDICINE is a discipline within biomedical and public health research that aims to improve the health of individuals and the community by "translating" findings into diagnostic tools, medicines, procedures, policies and education. PREVENTIVE MEDICINE consists of measures taken for disease prevention, as opposed to disease treatment. Just as health encompasses a variety of physical and mental states, so do disease and disability, which are affected by environmental factors, genetic predisposition, disease agents, and lifestyle choices. PERSONALIZED MEDICINE is a medical model that proposes the customization of healthcare - with medical decisions, practices, and/or products being tailored to the individual patient. In this model, diagnostic testing is often employed for selecting appropriate and optimal therapies based on the context of a patient’s genetic content or other molecular or cellular analysis. Wikipedia

7. NEW HEALTHCARE MODEL TRANSLATIONAL MEDICINE - PREVENTIVE MEDICINE PERSONALIZED MEDICINE PERSONALIZED HEALTH PRODUCT PERSONAL DATA BASED RECOMMENDATIONS FUNDAMENTAL AND APPLIED RESEARCH

8. FEATURES, OUTCOMES AND GOALS OF THE NEW MODEL OF HEALTHCARE PREVENTION EARLY DIAGNOSTICS TARGETED THERAPY DIRECT ECONOMICAL EFFECT INDIRECT ECONOMICAL EFFECT HEALTHIER POPULATION PRODUCTIVE LOGEVITY

9. SHORT HISTORICAL REVIEW PREVENTION starts with parents genetic testing and family consulting and continues with regular check-ups and biobanking NIKOLAY A. SEMASHKO (1874-1949) PREVENTION MEDICINE AS A SYSTEM, MOSCOW, 1926 EARLY DIAGNOSTICS including microbiome EVGENIY I. CHAZOV EARLY DIAGNOSTICS AT A NATIONAL LEVEL, USSR, 1970-s “REGULAR CHECK-UP SYSTEM” TARGETED THERAPY “Targeted therapy is one of the major modalities of medical treatment” Wiki V. Craig Jordan and Elwood V. Jensen on the occasion of learning they were going to be the inaugural recipients of the Dorothy P. Landon/AACR Prize (2002) for Translational Research. “Tamoxifen: catalyst for the change to targeted therapy” V. Craig Jordan Eur J Cancer. Author manuscript; available in PMC 2009 Jan 1.Published in final edited form as: Eur J Cancer. 2008 Jan; 44(1): 30–38. doi: 10.1016/j.ejca.2007.11.002

10. ECONOMICS PRODUCTIVE LOGEVITY IS THE ONLY WAY TO OVERCOME ECONOMICAL CRISIS OF THE AGING WORLD

11. What do we need to make Translation Medicine happen? 1.Understanding by society 2.Funds 3.Change of law and regulations including insurance coverage 4.Freedom for physicians in taking decisions 5.Deep patient’s involvement through the education and mass-media 6.Multidisciplinary trained professionals and joined teams

12. Who is the translational medicine specialist?

13. TEAM OF MULTIDISCIPLINARY TRAINED PROFESSIONALS PHYSICISTBIOTECHNOLOGIST (ACCORDING TO THE EXISTING REGULATION) PHYSICIAN RESEARCHER XX ANALYST XX

14. GENERAL TRAINING (APPLIED PHYSICS) (BS) TRANSLATIONAL MEDICINE (MS) BS DEGREE: 4 YEARS OF PHYSICS, 4 YEARS OF MATH, 3-4 YEARS OF CHEMISTRY, 2-3 YEARS OF BIOLOGY AND HUMAN PHYSIOLOGY 4 YEARS OF LAB WORK 1 YEAR OF RESEARCH MS: 1 YEAR OF PHYSICS 1 YEAR OF CHEMISTRY 1 YEAR GxP and ROSZDRAVNADZOR “Russian FDA” regulations 2 YEARS OF RESEARCH OPTIONS: DRUG DESIGN AND DEVELOPMENT MEDICAL EQUIPMENT RESEARH OMICS TECHNOLOGUES BIOINFORMATICS BIOCHEMISTRY BIOPHYSICS

15. PHYSICIANS TRAINING (PLAN) CERTIFICATION COURSES FOR BASIC SCIENCE AND FOR OMICS TECHNOLOGIES SEVERAL “MODULES” 16 HOURS EACH ACCORDING TO A NEW SYSTEM OF CONTINIOUS EDUCATION CREDUTS TO BE IMPLEMENTED FROM 2016 IN RUSSIA. THEORETICAL COURSES FOR THE WHOLE VARIETY PRESENTED IN MIPT AT THE CHAIR OF MOLECULAR AND BIOLOGICAL PHYSICS AND CHAIR OF THE INNOVATIVE PHARMACEUTICALS AND BIOTECHNOLOGIES LAB PRACTICE: STEM CELLS LAB GENOMICS LAB TRANCRIPTOMICS LAB PROTEOMICS LAB BIOINFORMATICS BIOANALITICS LAB (METABOLOMICS)

16. STAKEHOLDERS IN RUSSIA FEDERAL MEDICO - BIOLOGICAL AGENCY FEDERAL CLINICAL RESEARCH CENTER FOR PEDIATRIC HAEMATOLOGY, ONCOLOGY AND IMMUNOLOGY HEALTHCARE SYSTEM OF PRESIDENTIAL AFFAIRS NATIONAL SPACE AGENCY MOSCOW RESEARCH INSTITUTE OF EMERGENCY CARE MOSCOW RESEARCH INSTITUTE FOR ONCOLOGY CENTER FOR HEAMATOLOGY RESEARCH INSTITUTE FOR CLINICAL CARDIOLOGY BIOPHARMCLUSTER “NORTHEN” AND PARTHERS EXAMPLES OF 3 CNETERS PLANNED BY MIPT IN COLLABORATION WITH HOSPITALS AND VENDORS:

17. TRANSLATIONAL MEDICINE CENTER WITHOUT OMICS TECHNOLOGIES UNITED CENTER OF MIPT, FMSMU AND GEORGE WASINGTON UNIVERSITY FOR TRANSLATIONAL MEDICINE Application is pending Russian Speaking Academic Science Association

18. Translational medicine center No omics, only math modeling, radiology and interventional cardiology The idea behind is an establishing of the classification of human hearts by sizes and shapes for further design of a custom-made cardiac flexible electronics. At a moment center is about to start getting statistics.

19. ANGIOSURGERY PROGNOSIS

20. Virtual Fractional Flow Reserve Assessment

21. TRANSLATIONAL MEDICINE CENTER FOR ONCOLOGY data is provided by courtesy of R.G.C.C. and Natalilab Clinical data response in 254 cases complete response partial response stable disease progress of disease Response Number Percent Complete Regression 31 254 12,2 % Partial Regression 103 254 40,6% Minor Response 33 254 12,9 % Stable Disease 34 254 13,4 % Progression 26 254 10,2 % Treatment not started 27 254 10,7 % Response was assessed according to RECIST criteria after 2 years of follow up

22. CENTER FOR PERSONALIZED MEDICINE FMBA-MIPT PERSONALIZED ANTI-AGEING RESEARCH NUTRIGENETICS REGENERATIVE MEDICINE AND COSMETOLOGY TELMEDICINE

23. News of the day Ministry of Education and Science of Russia has just accepted our application for the first in Russia translational medicine program. 26-th of October 2015

24. THANK YOU FOR YOUR ATTENTION