1. Clotho in Kepler Help sharing Clotho’s awesomeness to the world Use scientific workflow to create, reuse, share and extend Clotho’s operations

2. Clotho at work Time : Need to open/close and work on many inner tools and operations Sharing Reuse: Do the same steps again in the future with small difference in input Future development and connection with other resource and software

3. The classical way Write down steps into notebook: open the DB Connection, then type in log in, then open Part Manger, then.. Take screenshot and write comment in details

4. Let there be workflows this will be a particular operation inside Clotho Ultimate Question of Life, Universe... Clotho Connect to database Clotho Sequence View Clotho Part Manager Clotho save to database PART # 42 Output Display Reverse compliment

5. What is Kepler & Scientific Workflows Large, automated computational process that divided into steps in a “flow” Integrating data, tools and resources into one user-friendly, drag&drop framework Capture, reuse and share

6. Each steps is an “actor”

7. Kepler Actors that is separate bio process: BOL Reverse Compliment Clotho ? Actors that Call Clotho’s operations Other software & resources

8. Problems Communicating between two separate Java programs Call Clotho’s process and output data back to the workflows. The data that return from Clotho’s process can be used by other actors Packaging Kepler with Clotho

9. Implementation Network programming. Java RMI (Remote Method Invocation): one program can call method of objects from another program (JVM). Run RMI separately with batch file API:. Run Clotho tools (SequenceView..) with input arguments (from previous steps), user only type in the

10. Timeline June : decide Clotho-Kepler connection, Clotho’s API Run one Kepler workflow with new actors July : Clotho’s API, Clotho actors, data input&output Data can flows between Kepler&Clotho August: actors, packaging actors, make abstractions