1. GENE INDEXING Janice Ward Indexer/Reviser Index Section, NLM

2. LocusLink http://www.ncbi.nlm.nih.gov/LocusLink/ Developed by NCBI Provides single query interface about genetic loci Includes links to/from PubMed/MEDLINE citations

3. LocusLink Content LocusLink presents information on: –Official nomenclature & aliases –Sequence accessions –Phenotypes –EC & MIM numbers –UniGene clusters –Homology –Map locations –Related web sites

4. Organisms Included in LocusLink Current scope of LocusLink is five organisms –Fruit fly –Human –Mouse –Rat –Zebrafish

5. Gene Indexing MEDLINE indexers assist creation of LocusLink by performing gene indexing Gene indexing - Creating annotated links between records in LocusLink and MEDLINE citations which contain information about a gene or protein

6. Selection of Articles for Linking Restrictions Restricted to the five organisms currently in LocusLink Restricted to genes or proteins in which an unambiguous link can be made

7. Selection of Articles for Linking Criteria Articles in which the basic biology of a gene or protein is a primary point Structure Isolation Function Most articles linked come from the preclinical literature -- few from the clinical

8. Gene Indexing Process Perform subject analysis of journal article Recognize articles that report information about a gene or protein appropriate for linking to LocusLink Search LocusLink for the gene or protein and create a link between LocusLink record and MEDLINE citation Provide short statement describing new information about gene or protein that is reported in article

9. Article to be linked

10. Gene Tab in DCMS

11. DCMS Gene Indexing Panel

12. DCMS LocusLink Query

13. LocusLink Record in DCMS

14. Full LocusLink Record

15. Gene Record added to DCMS

16. Completed Link

17. PubMed Link

18. LinkOut from PubMed

20. LocusLink Record

21. Gene Indexing In-house indexers trained at beginning of December 2001 417 items gene indexed in December 2001 438 items indexed in January 2002 Total of 1230 items gene indexed since start of pilot project in summer 2001