1. Proteomic Ka-Lok Ng Asia University

2. Topics to be covered Amino acids: the building blocks of proteins Dihedral angles (φandψ) in the backbone of biopolymers and the Ramachandran plots Tertiary structures of proteins: all-a topologies, all-b topologies, b barrels, the Greek Key topology, and the Jellyroll Topology, and a/b topologies (a/b horseshoe). Protein 1D, 2D and 3D databases: PDB, SCOP, CATH, DSSP, Uniprot Physical methods of determining the three dimensional structure of protein Protein folding in vivo and in vitro Protein structure prediction: homology, threading, ab inito prediction Protein-protein interaction network Protein structure and molecular approach to medicine X-ray and NMR Discussion of articles

3. 40% on quiz, classwork, homework, class attendance Mid-term, oral presentation – 30%, final exam. – 30%, oral presentation

4. References Orengo, Jones, and Thornton, Bioinformatics: genes, proteins, and computers. BIOS scientific Publishers (2003) Baxevanis A. and Ouellette B.F. Francis. Bioinformatics. J. Wiley (2005) Lesk A.M. Introduction to Protein structures Oxford University Press (2001).