1. Biomedical Informatics Research Network BIRN Workflow Portal

2. Biomedical Informatics Research Network Goals Allow mBIRN software to be consumed by both inside and outside groups on a consistent computing platform Able to integrate various different pipeline applications (LONI, Kepler, jBPM) into an analysis Infinite undo/redo from various points in an analysis; able to recalculate and compare results Possible to distribute computing to various sites by promoting web services

3. Biomedical Informatics Research Network Vision presented Oct 2005 Ontology Consent Discovery Data flowing Custom Interfaces A program Workflow DB Security

4. Biomedical Informatics Research Network Creation of Workflow Portal Started October 2005 Allows processing of standard workflows through main BIRN portal. Stabilizes many aspects of the environment used in a calculation. Allows publication of proprietary algorithms. Requires de-identification during a calculation. Results flow into standard database model for retrieval.

5. Biomedical Informatics Research Network

10. Architecture

11. BIRN Infrastructure Authentication Services (GAMA)Data Grid (SRB) BIRN-CC Development Environment

12. Biomedical Informatics Research Network SRB (File Repository) SRB ClientBIRN Portal or uploaddownload Web Server Request Form Kepler LONI WF driver (client) jBPM WF driver (server) Status of Request Check on Status and Continue GAMA authentication server Tomcat Server GridSphere WF portlet Interface SRB Client Interface DB Resting Final Report start task status

13. Biomedical Informatics Research Network SRB (File Repository) SRB ClientBIRN Portal or uploaddownload Web Server Kepler LONI WF driver (client) jBPM WF driver (server) GAMA authentication server Tomcat Server GridSphere WF portlet Interface SRB Client Interface DB Initialize Request Form Status of Request Check on Status and Continue Final Report start task status

14. Biomedical Informatics Research Network Request Form Status of Request Check on Status and Continue Final Report SRB (File Repository) SRB ClientBIRN Portal or uploaddownload Web Server Kepler LONI WF driver (client) jBPM WF driver (server) GAMA authentication server Tomcat Server GridSphere WF portlet Interface SRB Client Interface DB Starting start task status

15. Biomedical Informatics Research Network SRB (File Repository) SRB ClientBIRN Portal or uploaddownload Web Server Kepler LONI WF driver (client) jBPM WF driver (server) GAMA authentication server Tomcat Server GridSphere WF portlet Interface SRB Client Interface DB Running Request Form Status of Request Check on Status and Continue Final Report start task status

16. Biomedical Informatics Research Network SRB (File Repository) SRB ClientBIRN Portal or uploaddownload Web Server Kepler LONI WF driver (client) jBPM WF driver (server) GAMA authentication server Tomcat Server GridSphere WF portlet Interface SRB Client Interface DB Checking Request Form Status of Request Check on Status and Continue Final Report start task status

17. Biomedical Informatics Research Network SRB (File Repository) SRB ClientBIRN Portal or uploaddownload Web Server Kepler LONI WF driver (client) jBPM WF driver (server) GAMA authentication server Tomcat Server GridSphere WF portlet Interface SRB Client Interface DB Finished Request Form Status of Request Check on Status and Continue Final Report start task status

18. Biomedical Informatics Research Network Workbench Developement Web portal unable to accommodate: –Robust up/downloading of images with de- identification –Deployment of workflows to jBPM –Cooperative development –Robust displays of study results and calculations

19. Biomedical Informatics Research Network SRB (File Repository) SRB Client BIRN Portal or uploaddownload Web Server Kepler LONI WF driver (client) jBPM WF driver (server) GAMA Tomcat Server GridSphere WF portlet Interface SRB Client Interface DB Request Form Status of Request Check on Status Final Report start task status BIRN Workflow Workbench Allows direct creation of jBPM workflows Displays and control workflow progress Allow robust uploading to SRB Scalable to include results analysis with NCBC software Eclipse plug-ins

20. Biomedical Informatics Research Network

26. Future Goals Needed for March mBIRN AHM

27. Biomedical Informatics Research Network Complete the “productionizing” of the Portal workflow application Improve flow with the SRB – flow to the SRB both through the portal and through Jargon API. Improve functioning with GAMA authentication File management enhancements – a client plug-in in the Workbench that allows FTP-like interactions with the SRB with a robust file management UI Improve error handling and reporting – harden internal operation of workflow software. Incorporate view in Workbench for start, parameter entry, and status views to provide complete workbench solution Complete the support for Data Provenance with latest data provenance specifications.

28. Biomedical Informatics Research Network Workbench will be completed as Eclipse plug-ins

29. Biomedical Informatics Research Network Store and show results from workflow processes Finalize and provide documentation on method XML wrapper uses to expose database updates Finalize and provide manual for creating workflow ontologies Finalize and provide documentation on how to store results in the workflows database Render the results for a limited set of results Visualize results and download to BIRN infrastructure Show results by research subject

30. Biomedical Informatics Research Network Future Goals To come after others achieved

31. Biomedical Informatics Research Network Next 2 years if March Goals Achieved Streamline and possibly redefine BIRND-UP functionality so that images can be de-identified without user interaction Formalize web services so they can be evoked from the infrastructure of XNAT and HID Release workflow for gradient distortion correction algorithm that requires proprietary spherical harmonic information Work towards complete support of ADNI calculations ???

32. Biomedical Informatics Research Network BIRN Workflow Portal

33. Biomedical Informatics Research Network