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Experimental design and power analysis for systems biology Karlyn Beer 21 Aug 2012.

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Presentation on theme: "Experimental design and power analysis for systems biology Karlyn Beer 21 Aug 2012."— Presentation transcript:

1 Experimental design and power analysis for systems biology Karlyn Beer 21 Aug 2012

2 Do your research before you do your research

3 Statistical power Power = The probability of detecting an effect, given that the effect is really there.

4 Statistical power

5 Power and Sample size

6 Effect size (d) Δ Mean 1 Mean 2 How to calculate a pooled SD: http://en.wikipedia.org/wiki/Pooled_variance

7 Power, sample size and effect size (d)

8 1. Is miRNA expression associated with glioblastoma cases? Compare mean miRNA expression in glioblastoma case patients with non-GB controls Use a 2 sample t test We’ll explore how to handle different group sizes and a non-ideal dataset (not uncommon to have one..)

9 2. Is miRNA expression correlated with copy number in glioblastoma cases?

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