1. “The game is equalized”
Synergetic mechanism of the effects of anthrax and dental microbial plaque fragments at the design (fashion) of bio-weapons and/or cancer treatment
By Antonio Schütz
“Is not necessary to contaminate all an island to proof this mechanism!”
(TN2/ )
“The game is equalized”

2. Synergetic effect of Anthrax toxin and dental microbial plaque fragments (general mechanism)
Increases the secretion and synthesis
Improves the formulation of anthrax (aerosol
of free radicals
Mustard gas Dental plaque chemoatracts macrophages
Free Radicals: NO∙, O2- HOCL∙ RHNCL∙
and particularly paste powder – dry paste)
Increases of the synthesis and secretion of cytokines production by macrophages
Increases the effects of LF
Increases the effects of EF
Increases spores germination to become vegetative cells within macrophages
Impairs phagocytosis in macrophages
Increase of macrophages phagocytose and lyse endospores
Cancer Treatments
Oncogenic proteins (Ras) activate MAPKs
Expression of matrix metalloproteases
Apoptosis induction
Enzime NADPH oxidase iNOS, MPO
“Trojan horse”
Septicemia
Necrosis Apoptosis
Monocytes
Decreased lymphocytes function
[RANTES]
LPS Mustard gas
LPS Mustard gas
Chemokynes (MIP, IP-10, MCP-1)
IL-6
[IL-8]
[cytokines and growth factors vase-actives]
Hypothension

3. Synergistic effect of Anthrax toxin and dental microbial plaque fragments
The anthrax bacteria produce the anthrax toxin components—
protective antigen, edema factor, and lethal factor. Protective
antigen (PA) binds to the anthrax toxin receptor (ATR) on cell
surfaces and forms a protein-receptor complex that binds lethal
factor (LF) and edema factor (EF). The toxins enter the cell and
kill it. Most anthrax fatalities are caused by the irreversible effects
of the anthrax toxins on cells and tissues.
Apoptosis: LF (anthrax) and LPS (dental plaque) induce apoptosis via activation TLR
Septic
Shock
Acidogenic dental bacteria Increase the effects of PA

4. Gram-negatives of dental plaque
Endotoxins of Gran-negatives from dental microbial plaque increase the synthesis and secretion of tumour necrosis factor IL-1, NO, [PGs] as well as their effects (death, apoptosis, edema) induced by anthrax toxin.
Endotoxin of
Gram-negatives of dental plaque
TNF-α, IL-β [PGs], ON increasing death, apoptosis and edema]

5. Synergetic activation of NOS
Indomethacin [PGs] Interation with β-glucan
[TNF-α, IL-1]
Immunesuppression
LPS
Anthrax Dental plaque
[ET-1]
Death
Septicemia
Actives EF
Methotrexate [folate] Mustard gas
Ulceration of gastroinstestinal mucosa Nephrotoxicity
Free radicals
Apoptosis
cells
Increase the effect of EF
Oxidation of thiois
Lipid peroxidation
Edema

6. Synergistic activation of NOS increase the production of GMPc
Indomethacin [PGs]
LPS [PGs]
Death

7. ABthrax specifically recognizes and neutralizes protective
Evasion of complement and immune response by structural components ( polysaccharides, sialic acid, hyaluronic, LPS) and products of synthesis and secretion of microorganisms of the dental plaque (factor H, proteases, coagulases, A and M proteins, soluble antingen), such as stafilococcus, streptococcus able to block the production of ABthrax antibodies (vaccination)
ABthrax specifically recognizes and neutralizes protective
antigen (PA). By neutralizing PA, ABthrax effectively
blocks the binding of PA to cell surfaces and prevents the
anthrax toxins from entering and killing the cell.

8. Chemical components that increase immune-suppressor and/or citotoxic effects
Chemical substances with structure similar to Indomethacin and Methotrexate.
Triazole pesticides Inhibition of biosynthesis of steroids Low toxicity Ineffective against spores Peak in 14 days (at plants) Variable product formulation: dry and liquid flowables, wettable powders and emulsifiable concentrates
Mustard Gas

9. “The smart bomb”
Nanocells: A new nanoparticle drug-delivery system that makes it possible to combine drugs (anthrax, dental plaque and heterocyclic chemical) with different mechanisms of action in the same particle, and to design their temporal release with objective of obtaining the synergetic effect Is possible to rise the effects of anthrax toxins with simple addiction of cytokines (IL-1, TNF…), chemocynes (MIP, IP-10, MCP-1...) and growth factors ( ERGF…), LPS at concentration greater than 100 ng/mL, ON, PGs etc… In my experience with dental plaque (100 mG/mL) has its toxicity increased at the short time by indomethacin and methotrexate, possibly the same occur with chemical with similar structure.

10. Conclusion
As at the construction of a dress, the first phase is the design. The second is the selection of the color and texture of the tissue (laboratorial and clinical tests) that will be used in its construction; the third, the construction by competent dressmakers. So, the idea of the design is presented. Now, desire that the colleagues test it and elaborate the final product. If a dress originally draw for a fest is modified and used at a married, is secondary. For the designer what really import is the design of the idea. Desire this fashion may be useful for you and particularly to that (TN2/ ) incited me the idea of this design. Thank you very much.