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Presented By Fortunato Ciardiello at 2014 ASCO Annual Meeting

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Presentation on theme: "Presented By Fortunato Ciardiello at 2014 ASCO Annual Meeting"— Presentation transcript:

1 Presented By Fortunato Ciardiello at 2014 ASCO Annual Meeting
Treatment outcome according to tumor RAS mutation status in CRYSTAL study patients with metastatic colorectal cancer (mCRC) randomized to FOLFIRI with/without cetuximab Presented By Fortunato Ciardiello at 2014 ASCO Annual Meeting

2 Presented By Fortunato Ciardiello at 2014 ASCO Annual Meeting
Disclosure Information<br />Relationships Relevant to this Session Presented By Fortunato Ciardiello at 2014 ASCO Annual Meeting

3 Presented By Fortunato Ciardiello at 2014 ASCO Annual Meeting
CRYSTAL study design Presented By Fortunato Ciardiello at 2014 ASCO Annual Meeting

4 Presented By Fortunato Ciardiello at 2014 ASCO Annual Meeting
Background Presented By Fortunato Ciardiello at 2014 ASCO Annual Meeting

5 RAS mutation analysis: BEAMing
Presented By Fortunato Ciardiello at 2014 ASCO Annual Meeting

6 RAS mutation analysis: BEAMing
Presented By Fortunato Ciardiello at 2014 ASCO Annual Meeting

7 Presented By Fortunato Ciardiello at 2014 ASCO Annual Meeting
Study profile Presented By Fortunato Ciardiello at 2014 ASCO Annual Meeting

8 Other RAS mutations: CRYSTAL
Presented By Fortunato Ciardiello at 2014 ASCO Annual Meeting

9 Other RAS mutations: first-line studies
Presented By Fortunato Ciardiello at 2014 ASCO Annual Meeting

10 Comparison of RAS subgroups: <br />efficacy
Presented By Fortunato Ciardiello at 2014 ASCO Annual Meeting

11 Baseline characteristics
Presented By Fortunato Ciardiello at 2014 ASCO Annual Meeting

12 Efficacy: RAS subgroups
Presented By Fortunato Ciardiello at 2014 ASCO Annual Meeting

13 Efficacy: RAS subgroups
Presented By Fortunato Ciardiello at 2014 ASCO Annual Meeting

14 Progression-free survival
Presented By Fortunato Ciardiello at 2014 ASCO Annual Meeting

15 Progression-free survival
Presented By Fortunato Ciardiello at 2014 ASCO Annual Meeting

16 Presented By Fortunato Ciardiello at 2014 ASCO Annual Meeting
Overall survival Presented By Fortunato Ciardiello at 2014 ASCO Annual Meeting

17 Presented By Fortunato Ciardiello at 2014 ASCO Annual Meeting
Overall survival Presented By Fortunato Ciardiello at 2014 ASCO Annual Meeting

18 Efficacy: RAS subgroups
Presented By Fortunato Ciardiello at 2014 ASCO Annual Meeting

19 Safety: grade 3/4 adverse events
Presented By Fortunato Ciardiello at 2014 ASCO Annual Meeting

20 Presented By Fortunato Ciardiello at 2014 ASCO Annual Meeting
Conclusions Presented By Fortunato Ciardiello at 2014 ASCO Annual Meeting

21 Presented By Fortunato Ciardiello at 2014 ASCO Annual Meeting
Acknowledgments Presented By Fortunato Ciardiello at 2014 ASCO Annual Meeting


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