1. Muscle Tissue Muscle tissue functions – Movement – Maintain Posture – Joint stabilization – Heat generation (11.5a)

2. Muscle tissue properties Contractility Excitability Extensibility Elasticity (11.5a)

3. Muscle tissue types Skeletal – Striated, voluntary Cardiac – Heart, striated, involuntary Smooth – Nonstriated, involuntary Table 10.2

4. Muscle tissue terminology Myofiber – A skeletal, cardiac or smooth muscle cell Myofilaments Protein “threads” within a myofiber 1.Actin – thin filaments 2. Myosin – thick filaments Sarcolemma – plasma membrane Sarcoplasm – cytoplasm

5. Skeletal Muscle C.T. Epimysium – surrounds entire muscle/organ Perimysium – surrounds muscle fascicle Endomysium – surrounds individual muscle fiber (10.1a)

6. THE CONNECTIVE TISSUE WRAPPINGS – A VIEW

7. Skeletal Myofiber (muscle fiber) Cylindrical – 10-100  m diameter – Varied length – up to entire muscle Formed by cell fusion Multinucleated – Peripheral nucleus Striated LM Demonstration Table 10.2

8. Sliding filament theory Muscle contracts by actin and myosin sliding past each other Myosin forms cross-bridges that attach to actin Cross bridges all swing in same direction and pull actin along Increased overlap of filaments results in contraction of muscle (10.6)

10. Sliding filament theory Actin and myosin do not shorten A band does not change I band shortens Sarcomere shortens (10.7)

11. The Neuromuscular junction Neuromuscular Junction Axon terminal – Mitochondria – Synaptic vesicles – ACh Synaptic cleft Motor end plate – AChR – AP to muscle fiber (14.5ab)

12. Sarcoplasmic reticulum SR surrounds each myofibril Stores Ca ++ – Release Ca ++ for contraction – Ca ++ uptake for relaxation (10.8)

13. Muscle contraction Signal to axon terminal ACh released AChR activated Muscle excited Excitation travels down t-tubule SR releases Ca ++ Ca ++ activates sliding filament process Muscle contracts http://www.blackwellpublishing.com/matthews/myosin.html (14.5b)

14. VIEW OF MYOFILAMENT STRUCTURES

15. Motor Unit Definition: a motor neuron and all the muscle fibers it innervates. When a motor neuron fires, all muscle fibers in the motor unit contract. – All or none principle A motor unit may contain hundreds to four muscle fibers (average ~ 150) Each muscle fibers receives one NMJ (14.6)

16. Summary: skeletal muscle fibers muscle fascicle fiber myofibril Myofilaments :actin & myosin Table 10.1

17. Cardiac muscle Only in heart Sliding filament theory Striated No NMJ 18.4

18. Cardiac muscle cells 15  m wide X 100  m long Branched Intercalated discs – Desmosomes adhesion – Gap junctions transmit electrical impulses Forms two networks – atrial and ventricular (10.10a)

19. Cardiac muscle cells Central 1-2 nuclei Mitochondria – numerous Less SR Fewer T tubules Myofibrils Sarcomeres – A band – I band – Z disc – H zone – Striated (10.10cd)

20. Smooth muscle Six major locations – Blood vessels – Respiratory system – Digestive system – Urinary system – Reproductive system – Eye (lens and iris) Siding filament theory applies – Actin & myosin – No myofibrils – no striations

21. Smooth muscle fibers Spindle shaped – 2-10  m diameter – 20-200  m long Nonstriated Central nucleus Arranged in sheets – Usually in layers around a tube – Peristalsis - waves of contraction to propel contents along tube (10.12b)

22. Smooth muscle properties Slower to contract vs. skeletal muscle Slower to relax vs. skeletal muscle Can maintain contraction longer Resistant to fatigue Unconscious control – ANS – autonomic nervous system – Stretch – Hormones

23. Smooth muscle organization Single unit innervation – Smooth muscle fibers connected by gap junctions – Network receives single innervation – Coordinated contraction Multiunit innervation – Each fiber innervated – Locations Iris of eye Arrector pili muscle of skin