1. Automated Metered Dose Inhaler Presentation #4 (03/22/04)
Presented By Group 11:
The “MDI Auto-Maniacs”
Maria del Carmen Carrillo
Jennifer B. Struble
Loyrirk Temiyakarn

2. Problem Definition
Automatic Metered Dose Inhalant (MDI) delivery device:
Electromechanical, in-hospital inhalant drug delivery system
Patients are mechanically ventilated and sedated
Medication delivered automatically as prescribed electronically
Medication must be well shaken (homogenized with propellant)

3. Background What is a Metered Dose Inhaler? Who Uses Them? Setting?
pocket-sized handheld inhaler
delivers standardized dose of medication for bronchodilation
Who Uses Them?
Patients with asthma or chronic obstructive pulmonary disease (COPD)
Setting?
Critical patients in hospitals
Prescriptions for outpatient or in-home use
Suspension of microcrystalline Albuterol in propellant (blahdy blahdy blah)

4. Existing Methods Methods in-use Patent Search Manual administration
Automatic methods are NOT for mechanically ventilated patients

5. Design Factors Integration with existing endotracheal tubing
Homogenization with propellant
Delivery of medication into ventilation system
Tubing length
Synchronization of delivery with breathing
Software/Automation
User interface
Prescription error checking

6. Project Status Preliminary Research Complete Completed Research
Standard MDI
Completed Research
Endotracheal Tubing
Connectors
Ventilators (Siemens Servo I)
Types of Medication
Continuing Research
Homogenizer
Standard MDI: Typical of other aerosol canisters but prefab can only allows a certain dosages regardless of how long it is pressed. Administering the dose can be easily mimicked using tubing instead of the plastic holster. Limitation is that the doctor can’t change the amount administered at one time.
Endotracheal Tubing: Relatively standard. Have connectors already being used for other applications. See nebulizer and AnaConDa
Ventilators: Doesn’t matter what brand ventilator is used. However, each dose has to be synchronized with inhalation.
Types of Medication: Using Albuterol primarily.
Homogenizer: Depending on where our device interfaces with the tubing, how close to the patent the medicine sits, determines how strong of a homogenizer can be used without disturbing the patient.

7. Working Design: Using Prefabricated Canisters
Integrated with existing tubing
In-line using AeroChamber
Homogenize
Pneumatic Actuator
Laptop-based prescription entry
Similar to error reduction system, Guardrails® Safety Software, in Alaris “Smart” IV Pump

8. Shaking = Homogenization
Key obstacle - homogenization
Actuator - homogenize and administer Albuterol
Pneumatic
Simple singular directional motion
Control stroke length
Detect position

9. Experiment on Homogenization
Overall - Difficult to quantify and so based on subjective analysis
Soft vs. Vigorous Shakes - Soft more effective
Various Vigorous Shakes - One worked better than two
Various Soft Shakes - Five better than three or ten
With the Spacer - ineffective, has to be inhaled to leave the spacer

10. Timeline Completed Work Current Work Timeline Preliminary research
Clearly defined design factors
Through Innovation Workbench
Testing with Albuterol
Current Work
Discuss with Festo rep.
Order more components to start building prototype
Actuator (pneumatic)
Building Model A
Timeline
Order parts ~ immediate
Model A ~ End of March
Testing ~ End of March
Final prototype ~ April
Software included
Mention the need to set up a time to talk financing with Dr. King

11. References http://familydoctor.org/040.xml http://www.medlineplus.com/
Hudson RCI. AnaConDa™ Principles of Operation. 2003