3. Hearts in Different Vertebrate Groups Obj 12

4. The challenge of multicellularity Being >2 cells thick creates problems for those on the inside How to breath? Eat? Get rid of waste? Exchange calls for lots of surface area many tiny vessels need a major mover

5. Functions of the circulatory system Supply metabolically active cells with food Glucose, fats, amino acids O 2 Remove wastes Nitrogenous wastes Metabolic H 2 O CO 2 Others (homeostasis, immune response)

6. Planaria Aquatic, small, and high surface area Receives O 2 and releases CO 2 by diffusion No true circulatory system

7. Terrestriality and larger body size selected for adaptations for nutrient and gas transport http://designmatrix.wordpress.com/2010/02/25/circulatory-systems/

8. Universal solutions Move stuff from where it is to where it isn’t Circulatory system is transit Respiratory system provides gas exchange

9. Fish: Simple Heart This and following heart figures (unless otherwise noted) from http://bio1151.nicerweb.com/doc/class/bio1151/ Under Pressure?

10. Lungfish A ‘sometimes’ circuit useful when no water Lungfish photo credit: http://animals.howstuffworks.com/fish/lungfish-info.htm from Sadava, Life, pp. 1048-9

11. A commitment to lungs comes with a dedicated circuit Amphibian: Increased Separation

12. Two aortas for a stop-and-go metabolism Periods of low metabolism (no need to maintain constant body temp!!); option to skip the lungs Reptiles: Bypass

13. Crocodilians: Better bypass The underwater option: 4 chambers, lung-skipping Croc vales ‘actively controlled’: not just resistive to backflow, can be ‘set’ open or closed. Why send blood to the lungs when there’s no air there? http://www.iucncsg.org/pages/The-Crocodilian-Body.html

14. http://media.web.britannica.com/eb-media/62/117362-004-C401D1FD.gif

15. Why might hearts get fancier? “Four-fifths of a mammal’s food consumption is invested in keeping it warm. A reptile has much lower running costs – about one-tenth of the food needed by an endotherm of the same size” The Book of Life, Stephen Jay Gould, ed. p. 129

16. Mammals, birds: Closed circuit Full-blown compartmentalization Flight and body temp maintenance place huge metabolic demands on the system. Blocking all possibility of leakage (assuming development went well) means max delivery of deoxy blood to lungs; oxy blood to tissues.

17. Do the 4-chambered hearts of birds and mammals most likely represent common ancestry or convergent evolution?

18. Hearts… Fish – 2-chambered. Why is this ‘okay’? Amphibians – 3-chambered. Why is this okay? Reptiles – 3-4-chambered; pretty well developed septum keeps blood separate. “Warm Bloods” – 4-chambered hearts

19. Questions on 13-15? rbc – “no” organelles: nucleus, mitochondria, ribosomes!, etc. Can’t divide and “make new cells” Yet, you produce over 2 million NEW rbc’s per second!!! “Short” life span ~ 100 days Takes about 30 seconds to circulate

20. Questions on 13-15?

21. HEMOGLOBIN!!

22. Hemoglobin 250-300 MILLION per rbc Made of four subunits (2 and 2)

23. Hemoglobin 250-300 MILLION per rbc Made of four subunits (2 and 2) Hb in blood, MYOglobin in muscles VERY similar molecules Myoglobin binds oxygen ‘better’

24. Hemoglobin vs Myoglobin Myoglobin binds oxygen ‘better’

25. Obj 17 CO 2 and O 2 Why hemoglobin? Let’s see what you remember… Gaseous oxygen is O=O; chemically what does this mean? What is MOST of your blood? Hb binds O2 so it can be carried Carbon dioxide is O=C=O; same thing

26. Obj 17 CO 2 and O 2 Hb doesn’t bind CO2 as well But it combines with water (with enzymes from rbc) to form carbonic acid This WILL dissolve in blood Lower pH DECREASES Hb’s ability to bind O 2 !

28. Blood and your Brain Your ‘brain’ monitors blood pH When it drops, respiration increases Hyperventilation?

29. Back to Fetal Circulation… If Hb binds oxygen, why would the mother’s Hb give it up AT THE SAME POINT the fetus binds it? Different Hb! Fetal Hb has a higher affinity for oxygen!

30. Back to Fetal Circulation…

32. Your turn Obj 20

33. Homework Obj 23 due tomorrow Find diseases that are interesting to YOU!!! Turn it in