3. Prostate Cancer – a model of Epigenetic Catastrophe? A Perry et al,, End. Rel. Cancer 2006

4. PBOX-15 induces apoptosis in primary B-CLL cells Propidim Iodide Annexin V - FITC control 1  M PBOX-15 n=34 p < 0.0001 Paired t test, t = 13.69, 33df

5. Hypoxic induction of CD gene expression HREPromoterCD HIF1-  HIF1-  HIF-1 Localised chemotherapy Sensitisation of hypoxic cells Improvement of RT outcome?

6. Legends to Figures Figure 1: Identifying a haplotype linked to risk of developing Myeloma by SNP pathway analysis Figure 2: Evolutionary Conservation of the SNP in XRCC5 linked to Myeloma Figure 3: Prostate Cancer, a model of Epigenetic catastrophe? The figure indicates some of the potential target of epigenetic modification in prostate cancer Figure 4: PBOX compounds as anti-leukaemia agents – demonstration of efficacy in primary CLL cells Figure 5: Promoting targeted killing of tumour cells through a suicide gene therapy approach