1. Cells and Disease

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3. Activity 2: Cells and Disease Get Started  Where do you think cells are involved in life processes?  Why do you think scientists and doctors study cells?

4. Activity 2: Cells and Disease Introduction  A disease is any breakdown in the structure or function of an organism. Read the introduction.

5. Activity 2: Cells and Disease  How do observations of cells help doctors and scientists diagnose and study diseases? Challenge

6. Activity 2: Cells and Disease Using a Microscope

7. Activity 2: Cells and Disease Procedure  Read the patient histories and table of possible diseases before you get your microscope slides.  Compare each patient’s blood sample to the typical blood sample. Part B: Observing Blood

8. Activity 2: Cells and Disease

9. Follow Up  What diagnosis did you give to Patient A, and what was your evidence?  What diagnosis did you give Patient B, and why?

10. Activity 2: Cells and Disease  Observe the diagrams below. Which patient would you diagnose with sickle cell disease? Explain, using evidence from this activity. Analysis 3 Patient 1Patient 2

11. Activity 2: Cells and Disease  Based on the diagrams, how does the shape of normal red blood cells help them perform their function? How does the shape of sickled red blood cells prevent them from performing their function?

12. Activity 2: Cells and Disease Follow Up  How do microscope observations of cells help doctors and scientists diagnose and study diseases? Give specific examples from this activity. Analysis 4

13. Activity 2: Cells and Disease  From what you learned about malaria in the case study: ◦ A trade-off is an exchange of one thing in return for another, giving up something that is a benefit or advantage, in exchange for something that may be more desirable. What are the trade-offs of using insecticides to kill the mosquitoes? ◦ What are the benefits of using insecticides to kill mosquitoes that might be carrying Plasmodium? Analysis 5

14. Activity 2: Cells and Disease  How do observations of cells help doctors and scientists diagnose and study diseases? Revisit the Challenge

15. Activity 2: Cells and Disease Key Vocabulary  cell  disease  infectious disease  malaria  microbe  mutation  noninfectious disease  protein  protist  sickle cell  trade-off  vector Key Vocabulary