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Vessels, Organs and Tissues
Lymphatic System Vessels, Organs and Tissues
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Lymphatic System Vessels: Connect to CV Organs: house immune cells
Capillaries Collecting vessels Trunks Transport fluid => lymph Organs: house immune cells LN Spleen Thymus Tissues Tonsils GALT MALT
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Fluid Compartments Capillary Dynamics Fluid Compartments
Hydrostatic/Hydraulic Osmotic Fluid Compartments ICF ECF ISCF Plasma Lymph
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Lymphatic Capillary
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Lymph Flow
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Lymphatic Valve
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Lymphatic Vessels and Ducts
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Thoracic Duct
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Lymph Return
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Problem Lymph Return : Lymphedema
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Lymphatic Vessel Circuits
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Lymph Node: Location
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L.N. : Specimen
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Lymph Node: Gross Anatomy
1. Afferent Lymphatics 2. Cortex 3. Germinal Center 4. Capsule 5. Medullary cord 6. Valve 7. Efferent Lymphatics
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LN Structure: CT and vessels
Capsule Subcapsular sinus Trabecula Reticular CT stroma Vessels Types Afferent Efferent Valves
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Lymph Node
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Lymph Node: Histology B cells T cells MO
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Lymph Node: Capsule Region
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Lymph Node: Cortex Lymphatic Nodule Germinal Center
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Lymph Node: Medulla
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Lymph Node: Medullary Cords
Sinusoids Macrophages
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L.N. Medullary Cells P = Plasma cells (daughter cells of Activated B cells M = Macrophages (mature monocytes in tissues)
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LN Histology Summary
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Diagnostics for Lymphatics and LN
Lymphangiogram
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Lymphatic Problem: Lymphoma
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Lymphatic Nodule: Basic structure for All Lymphatic tissue
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Spleen: Location
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Spleen: Gross Anatomy
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Spleen: Histology Splenic Sinusoid
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Spleen Problems Rupture Cancer Infection Hydatid cyst
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Thymus: Location
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Thymus: Gross
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Thymus Embryological Development
1. Mandibular arch 2. Hyoid arch 3. Cervical sinus entry 4. 3rd pharyngeal pouch 5. 4th pharyngeal pouch 6. Foramen cecum 7. Thyroid 8. Cervical sinus 9. Thymus (3rd pouch) 10. Thymus (4th pouch)
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Thymic Cell Development
1. Thymic capsule 2. Thymic nurse cells 3. CT septa and BV 4. Subcapsular epithelium (for the blood thymus barrier) 5. Cortical Epithelial cells 6. Medullary epithelial cells 7. Dendritic cells 8. Hassall’s Corpuscle 9. Macrophages 10. Cortex 11. Medulla
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Thymic Organization
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Thymic Capsule, Septa and Lobules
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Thymus: Cortex
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Thymic Medulla
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Thymic Age Degeneration
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Thymic Problem Thymic Aplasia
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Tonsil: Location Pharyngeal [Adenoids] Palantine Lingual Tubal
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Palatine Tonsil
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Tonsil: Epithelial Histology
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Tonsil Lymphatic Nodules
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Tonsilar Crypt
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Tonsil Problem: Tonsillitis
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Gut Associated Lymphatic Tissue (GALT) Location
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GALT
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Peyer’s Patches
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Ileum Problems Inflammation Necrosis
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Appendix: Gross
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Appendix
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Appendix Problems Appendicitis Appendix rupture and necrosis
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MALT epiglottis bronchus
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Summary Overview
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Questions?
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