1. CLINICAL EPIDEMIOLOGY III: JOURNAL APPRAISAL Group 3 February 11, 2010

2. Case Scenario CA, 20, Female has an anterior cystic mass that started to grow in the area since she was 3 years old. The cystic mass is exactly at the midline at the level of the thyroid cartilage. This is smooth, well circumscribed, non tender and moves up when the tongue is protruded.

3. Salient Features 20 y/o, female Anterior cystic mass; exactly at midline, level of thyroid cartilage Smooth, well circumscribed, non tender and moves up when the tongue is protruded

5. The pre – test probability was set in 7% based on: Thyroglossal tract remnant occurs in 7% (which is usually asymptomatic) of the total population and only 20% occur at ages 20-30 years age. TTR/TDC is more common on pediatric patients which occur at around 30%. The incidence of ectopic thyroid tissue, misdiagnosed as a thyroglossal tract remnant, is probably between 1 and 2%, according to a series by Radkowski et al which makes our pretest probability much lower. Mostly thyroglossal duct cyst is diagnosed early and intervention is well established. Most adult patient at peak of around 4 th decade has greater incidence for a malignancy.

6. Is there a role for ultrasonography in the pre-operative diagnosis of TDC? Population: thyroglossal duct cyst Intervention: ultrasonography Outcome: preoperative diagnosis Methodology: retrospective cohort Search terms: – Thyroglossal duct cyst AND sonography AND preoperative diagnosis

8. Article was obtained using the PUBMED

11. Article

12. CRITICAL APPRAISAL OF AN ARTICLE ON DIAGNOSIS

13. Was the objective of the study relevant to my clinical question? YES. RELEVANCE

14. VALIDITY GUIDELINES Was there an independent comparison with a reference standard? It was not stated in the article whether or not there was an independent comparison between sonography and the reference standard used, histopathology findings.

15. VALIDITY GUIDELINES Did the patient sample include the spectrum of patients to whom the test will applied in practice? YES. Although, there was no mention of the age range of the pediatric patients, all patients had cystic midline neck masses at the vicinity of the hyoid which is a characteristic of thyroglossal duct cysts.

16. VALIDITY GUIDELINES Was the reference standard done regardless of the result of the test being evaluated? YES. Pathological confirmation was done in all patients post-operatively.

18. VALIDITY GUIDELINES Were the methods for performing the test described in sufficient to permit replication? YES.

19. OVERALL, Is the study valid? YES. The study met most of the criteria for a valid study.

20. WHAT ARE THE RESULTS? What were the likelihood ratios for the different possible test results? Sensitivity: 99% Specificity: 95% LR (+): 19.8 LR (-): 0.01

22. MANAGEMENT Management will be dependent on which part of the spectrum the computed post test probability will fall Computed post test probability: If positive for US = 1.58 / (1.58+1) = 60% If negative for US = 0.0008 / (0.0008+1) = 0%

24. RESULTS Will the reproducibility of the test result and its interpretation be satisfactory in my setting? There was no clear way of how the results were actually interpreted and how they were able to come up with the sensitivity and specificity of the test.

25. RESULTS Are the results applicable to my patient? YES. Since the disease is actually very rare and the findings of ultrasonography are highly specific, then it may be applied to our patient and although the age range of the patients (pediatric) is different from our patient (20 years old- adult), their clinical presentation is similar..

26. CLINICAL BOTTOM LINE Ultrasound may be used as a pre-operative diagnostic tool for thyroglossal duct cyst however the clinical findings may already suffice.

27. RESOLUTION OF THE PROBLEM IN THE SCENARIO Our patient, having all the classical findings of thyroglossal duct cyst may therefore undergo surgical intervention without the necessity of an ultrasonography.