1. Family Secrets Problem Based Learning

2. Family Secrets Part 1: A Family Disease Part 2: The Test Part 3: A Difficult Choice Part 4: Testing for the HD Gene Part 5: Making Decisions

3. Team Roles Secretary Recorder Spokesperson

4. In Part I, you will  Learn about a family with a history of a genetic disease.  Listen to a short reading.  Make lists of Facts and Questions.  Practice brainstorming rules.

5. Class read aloud Part 1: “A Family Disease” Listen to reading On the sheet provided write Facts that you know from the reading Develop Questions that you have

6. Family Secrets Part 2, you will  Read another short narrative  List new Facts and Questions  Categorize Questions

7. Categorize Questions Risks and Cause (RC) Symptoms and Prognosis (SP) Diagnosis and Treatment (DT) Family Issues (not researchable) (FI)

8. Topical Barometer If you were Jenny, would you have genetic testing for Huntington’s disease? Put your name on a Post-It note and place the note on the Topical Barometer continuum. ________________________________________________ Definitely Maybe Not Sure Maybe Definitely Yes Yes No No

9. Teams organize for research Assign each team member a different category of Questions Each team member will become a “Category Specialist” Write the heading of your category on the Individual Research Log

10. Jigsaw 1  Category Specialists meet to share research Diagnosis And Treatment Family IssuesRisks and Cause Symptoms And Prognosis

11. Family Secrets Part 3 A Difficult Choice

12. Class read aloud Part 3: A Difficult Choice Class read aloud Part 3: A Difficult Choice Listen to reading Underline or highlight important Facts

13. An Ethical Issue or Dilemma …. a situation that requires a decision or an action that involves competing ethical principles and values. …. a situation that requires a decision or an action that involves competing ethical principles and values.an

14. Rank each principle in order of importance to you  Right to decide (Autonomy)  Do what is best (Beneficence)  Do no harm(Nonmaleficence)  Do what is fair (Justice)

15. Rank your “top 3” values  Actions to relieve the suffering of others Compassion  Keeping a secret Confidentiality  Keeping a promise; fulfilling an obligation Fidelity  Treating others as you would like to be treated Golden Rule  Telling the truth Honesty  Conforming to your own ethical principles/moral values Integrity  Keeping from public view Privacy  Preserving the dignity of self and others Respect

16. Ethical Decision-Making Process: By yourself…. 7. Based on the chart and the ethical principles and values that are important to you…. What do you think is the best course of action?

17. Modified Topical Barometer #2 If you were Jenny, would you have genetic testing for Huntington’s disease? ________________________________________________ DefinitelyDefinitely Yes No Yes No

18. Reflection Questions Barometer Conclusions and Conversation: What conclusions would you make after seeing bothHuntington Disease: What is it? Topical Barometers? Huntington Disease: What is it?Huntington Disease: What is it? If you shifted your position on the Topical Barometer, explain why.

19. Homework Have students read and fill out the Informed Consent Form

20. Part 4: Lab Powerpoint Gel Electrophoresis Family Secrets Copyright © 2004, University of Rochester

21. Agarose Gel

22. DNA

23. DNA and Electrical Current

24. + -

27. + -

28. Part 5 The Future Fill out the Genetic Testing Laboratory Report – discuss results Read Part 5 Scenario Discuss the future for the Lanahan Family