1. Stent Redesign Whit Miller BME Senior Design Spring 2001

2. Market Analysis In 1999, US Physicians performed over 500,000 PCTA procedures involving a stent placement Within one year of de- ployment, 50% of stents illicit a restenosis.

3. Making a Better Mousetrap Current stents are bare metal A covered stent would have at least two advantages Limit SMC proliferation at the deployment site Expedite endothelialization

4. SES Vs Balloon-Deployed Self-Expanding Stents are considered superior for two reasons Maximize deployment precision Minimize catheterization time

5. Current Technology Best of the Current Covered SESs The Wallgraft and Corvita

6. The need for improvement Current covered SES have limited proven ability to prevent restenosis Neurovascular interventionalists have limited options for cerebral stenting

7. Project Goals Select a stent covering Covering will be mated with superior stent design Investigate commercial polymers and cadaveric decellularlized material Subject covering to filtration, deployment constraints