2. Circulatory System 9.3

3. Blood & Blood Cells  Blood is a tissue of fluid & cells  plasma  liquid part of blood  dissolved salts, sugars, proteins, and more  cells  red blood cells (RBC)  transport O 2 in hemoglobin  white blood cells (WBC)  defense & immunity  platelets  blood clotting

4. Blood Cell production  Stem cells  “parent” cells in bone marrow  differentiate into many different types of cells white blood cells red blood cells white blood cells

5. Red blood cells  Small round cells  produced in bone marrow  5 liters of blood in body  5-6 million RBC in drop of human blood  last 3-4 months (120 days)  filtered out by liver  ~3 million RBC destroyed each second

6. Hemoglobin  Protein which carries O 2  250,000 hemoglobins in 1 red blood cell O2O2 O2O2 O2O2 O2O2

7. Blood clotting protein fibers build the clot emergency repair of circulatory system platelets seal the hole chemical emergency signals

8. Blood donation clotting

9. Blood type blood type antigen on RBC antibodies in blood donation status A type A antigens on surface of RBC anti-B antibodies __ B type B antigens on surface of RBC anti-A antibodies __ AB both type A & type B antigens on surface of RBC no antibodies universal recipient O no antigens on surface of RBC anti-A & anti-B antibodies universal donor Matching compatible blood groups is critical for blood transfusions A person produces antibodies against foreign blood antigens

10.  http://www.nobelprize.org/educational/medicine/blo odtypinggame/game/ http://www.nobelprize.org/educational/medicine/blo odtypinggame/game/ Blood Typing Game

11. Label the Heart!

12. Mammalian heart Coronary arteries to neck & head & arms

13. Vertebrate Heart  4-Chambered heart  atria (atrium)  thin wall  collection chamber  receive blood  ventricles  thick wall pump  pump blood out right atrium left atrium right ventricle left ventricle

14. Mammalian circulation What do blue vs. red areas represent? pulmonary systemic

15. AV SL AV Heart valves  4 valves in the heart  flaps of connective tissue  prevent backflow  Atrioventricular (AV) valve  between atrium & ventricle  keeps blood from flowing back into atria when ventricles contract  “lub”  Semilunar valves  between ventricle & arteries  prevent backflow from arteries into ventricles while they are relaxing  “dub”

16. AV SL AV Lub-dub, lub-dub  4 valves in the heart  flaps of connective tissue  prevent backflow  Heart sounds  closing of valves  “Lub”  force blood against closed AV valves  “Dub”  force of blood against semilunar valves  Heart murmur  leaking valve causes hissing sound  blood squirts backward through valve

17. Circulation Olympics!

18.  http://sciencereviewgames.com/srg/games/gong.php? id=115 http://sciencereviewgames.com/srg/games/gong.php? id=115 Grade or No Grade?

19.  http://sciencelearn.org.nz/Contexts/See-through- Body/Sci-Media/Animation/Label-the-heart Label the Heart

20.  http://www.teachingideas.co.uk/science/circulatorysy stem.htm http://www.teachingideas.co.uk/science/circulatorysy stem.htm  Come in one group at a time and have to go through the heart right Floor Activity?