1. Firms that produce, analyse, or use biological systems on a micro-, cellular-, or molecular level or firms that develops tools and supplies for these purposes. Biotechnology Food Agriculture Pharmaceuticals Medical Technology Forestry Pulp & Paper Environment Instruments & equipment Chemistry THE BIOTECH INDUSTRY:

2. Agrobiotechnology - plant improvement and biological plant protection Bioproduction - biomolecular or micro-organism production Biotech tools and supplies - services, processes, equipment and instruments for biotechnological use Environmental biotechnology - soil, water, and waste treatment Functional food and feed - mainly probiotics Pharmaceuticals and medicine - drug discovery and drug development, diagnostics and medical technology The Swedish biotech industry

3. Number of biotechnology companies in different countries year 2000 Source: The Swedish Trade council, ”Global perspectives on bioscience 2002” *

4. Number of companies and employees Year 2677 3233 3391 3760 3975 0 20 40 60 80 100 120 140 160 180 200 19971998199920002001 0 500 1000 1500 2000 2500 3000 3500 4000 4500 Number of companies Number of employees

5. The regional distribution of the Swedish biotech industry 1999* * The sizes of the circles are proportional to the number of employees/companies. Only micro-, and small sized companies (<200 employees) are included. The distribution is based on the seat of the county government. No. of employeesNo. of companies

6. Number of companies

7. Number of employees 0 500 1000 1500 2000 2500 19971998199920002001 Agrobiotechnology Bioproduction Biotech tools & supplies Environmental biotechnology Functional food & feed Pharmaceuticals & medicine Number of employees Year

8. Turnover

9. Number of companies pharmaceuticals & medicine

10. Number of employees in pharmaceuticals & medicine 0 200 400 600 800 1000 1200 19971998199920002001 Diagnostics Drug delivery Drug discovery & development Medical technology Number of employees Year

11. Median equity/assets ratio Year 20 30 40 50 60 70 80 1997199819992000 Finacial strength, median (%) Agrobiotechnology Bioproduction Biotech tools & supplies Environmental biotechnology Functional food & feed Pharmaceuticals & medicine

12. Net profits/losses in surviving companies in the different biotech sectors, 1998 – 2001

13. Share of surviving companies with net profit 1998-2001 in total and in each sector

14. Size of sector in Sweden PHARMACEUTICALS AND MEDICAL TECHNOLOGY Approximately 30 000 employees and a turnover of 60 billion SEK BIOTECHNOLOGY The fourth largest biotechnology industry in Europe after Great Britain, Germany, and France * and the ninth in the world** 183 SMEs (< 500 emp. each), increase by 35% 1997-2001 About 4000 employees, increase by 48% 1997-2001 Turnover 4.4 billion SEK (2000), increase by 30 % 1997-2000*** Increased financial strength and net losses 1997-2001 * European Commission; Ernst & Young ** The Swedish Trade Council *** Fixed prices

15. Reasons for the development UNTIL 1999 The science base The presence of Astra and Pharmacia An internationally growing market Success stories inspires Changed attitudes Good availability of seed and venture capital CHANGE DURING 2000-2002…2003 Development at the stock exchange Cautious venture capital companies Lack of seed capital

16. The Swedish science base in international comparison THE SWEDISH SCIENTIFIC PERFORMANCE IN GENERAL The trend is increased quantity but at the same time there are signs of decreasing quality. PERFORMANCE IN A SELECTION OF LIFE SCIENCE FIELDS First, second or third ranking of publication volumes in relation to population in the selected seven subject fields. Five out of seven fields showed increasing shares of the world’s total publication volume. Four out of seven fields showed increased citation levels but still Swedish citation levels are loosing their top position

17. 1986- 1989 1990- 1993 1994- 1997 1998- 2001 Total 87-01 Biochemistry & Biophysics 22222 Biotechnol & Appl Microbiol 34312 Cell & Developmental Biol 33222 Immunology 12222 Microbiology 22433 Molecular Biology & Genetics 22322 Neurosciences & Behavior 11111 Swedish ranking in relation to population 1986-2001

18. Relative citation levels in biochemistry and biophysics

19. Relative citation levels in neurosciences and behavior

20. Volume shares for the nine most productive Swedish public research organisations of the total Swedish publication volume in biotechnology-related science, 1987-2001

21. Co-authorship pattern between organisations with the largest publication volumes in biotechnology related science 1997-2001

22. ’ 0 1 2 3 4 Biochemistry & Biophysics Biotechnol & Appl Microbiol Cell & Developmental Biol Immunology Microbiology Molecular Biology & Genetics Neurosciences & Behavior 1987-1989 1990-1992 1993-1995 1996-1998 1999-2001 The Swedish percentage of the world´s total publication volume within a selection of life science fields during five periods (1987 - 2001)

23. Relative citation levels for Swedish articles within a selection of life science fields during 1987-1997 (Index world=1)

24. Inventor origin for biotechnology patents in the US patent system 1987-2001* * Sweden < 1%

25. 0 1 2 3 MEDICAL ELECTRONICS MEDICAL EQUIPMENT PHARMACEUTICALS BIOTECHNOLOGY MEAN ALL AREAS 1987-1989 1990-1992 1993-1995 1996-1998 1999-2001 Swedish inventor shares of the world’s total patenting volume during five periods in different areas compared to the Swedish average share in all fields 1987-2001

26. Number of patents for Astra and Pharmacia 0 10 20 30 40 50 60 70 80 19871989199119931995199719992001 YEAR NUMBER OF PATENTS AstraZeneca AB Pharmacia Corporation